肠道微生物在结直肠癌治疗中的作用和机制研究进展

Research advances on the role and mechanisms of gut microbiota in colorectal cancer therapy

摘要:

结直肠癌(colorectal cancer, CRC)因发病率和死亡率居高不下，且带来沉重的经济医疗负担而备受广泛关注。近年来，肠道微生物在结直肠癌预防、诊断及治疗过程中的关键作用逐渐受到人们广泛重视，为晚期疾病管理带来了希望。本文全面回顾了肠道微生物群在结直肠癌发病与进展中的作用及其潜在机制，并探讨了肠道微生物群在晚期结直肠癌全身系统治疗中的应用潜力，提出新策略和新见解，以改善晚期结直肠癌的诊断与治疗方法。

Abstract:

Colorectal cancer (CRC) remains a focal point of research due to its consistently high incidence and mortality, as well as the substantial economic and healthcare burdens it imposes. In recent years, the pivotal role of the gut microbiota in the prevention, diagnosis, and treatment of CRC has garnered increasing attention, offering promising avenues for the management of advanced stages of the disease. This article comprehensively reviews the involvement of the gut microbiota in the development and progression of CRC, elucidating the underlying mechanisms. Furthermore, it examines the potential applications of the gut microbiota in the systemic treatment of advanced CRC, with the aim of proposing novel strategies and insights to enhance the diagnosis and treatment of advanced CRC.