干扰素-γ诱导蛋白16调控天然免疫及病毒感染的研究进展

Research progress on the regulation of innate immunity and viral infection by IFN-γ inducible protein 16

摘要:

干扰素-γ诱导蛋白16 (interferon gamma-inducible protein 16, IFI16)是含pyrin和造血表达、干扰素诱导特性和核定位(hematopoietic expression, interferon-inducible nature, and nuclear localization, HIN)结构域的蛋白质(pyrin and HIN domain-containing protein, PYHIN)家族的重要成员，其独特的分子结构使其能够识别细胞内的多种核酸分子。作为一种关键的免疫调节因子，IFI16可通过多种途径参与天然免疫信号转导，在宿主抗病毒防御中发挥重要作用。本文综述了IFI16的分子特征及其在天然免疫和病毒感染中的调控机制，为抗病毒感染的治疗靶点及药物开发提供理论依据。

Abstract:

Interferon gamma-inducible protein 16 (IFI16), a pivotal member of the pyrin and hematopoietic expression, interferon-inducible nature, and nuclear localization (HIN) domain-containing protein (PYHIN) family, possesses a unique molecular structure that enables it to recognize diverse nucleic acid molecules within cells. As a key immunoregulatory factor, IFI16 participates in the transduction of innate immune signaling through multiple pathways and plays a significant role in host antiviral defense. This review systematically summarized the molecular characteristics of IFI16 and its regulatory mechanisms in innate immunity and viral infection, aiming to provide a theoretical basis for the development of therapeutic targets and antiviral drugs.