肠道菌群在酒精性肝病中的作用机制研究进展

Research progress in the role of gut microbiota in alcoholic liver disease

摘要:

酒精性肝病(alcoholic liver disease, ALD)是由于长期过量饮酒所致的肝脏疾病，是全球最常见的慢性肝病之一。目前尚无有效治疗方法来阻止或逆转该病，造成了严重的社会负担，其防治压力不断增大。近年来，学者们发现长期酗酒会导致肠道菌群结构和功能的显著改变，从而破坏肠道菌群的平衡，而肠道菌群的失调则会推动酒精性肝病的进展。因此，在一定程度上维持肠道菌群稳态可为该病的预防和治疗提供新的靶点。本文主要综述近年来肠道菌群及其代谢产物与酒精性肝病的研究及干预治疗进展，为今后研究其发病机制及治疗提供参考。

Abstract:

Alcoholic liver disease (ALD) is a liver disease caused by long-term excessive alcohol consumption and is one of the most common chronic liver diseases worldwide. At present, no effective approach is available for preventing or reversing this disease, causing a serious social burden and increasing the pressure for prevention and treatment. In recent years, researchers have found that long-term alcohol abuse can lead to significant changes in the structure and function of the gut microbiota, thereby disrupting the balance of the gut microbiota, which can promote the progression of ALD. Therefore, maintaining gut microbiota balance can provide new targets for the prevention and treatment of ALD. This article reviews the research and intervention progress of the gut microbiota and its metabolites in ALD in recent years, providing reference for future studies on the pathogenesis and treatment of this disease.