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微生物学报

嗜盐耐盐微生物抗盐胁迫相关离子转运蛋白研究进展
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国家自然科学基金(31860030);人社部2021年度高层次留学人才回国资助项目;青海大学青年科研基金(2022-QYY-15)


Advances in ion transporters associated with tolerance of halophilic and halotolerant microorganisms to salt stress
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    摘要:

    离子转运蛋白在维持细胞内pH稳态、离子动态平衡等方面发挥着重要作用。钠离子转运体和钾离子转运体在嗜盐耐盐微生物中广泛存在,其"保钾排钠"机制是微生物抗盐胁迫的两大策略之一。近年来,嗜盐耐盐微生物中许多新型钠、钾离子转运体被陆续发现,如RDD蛋白、UPF0118蛋白、DUF蛋白和KimA蛋白等;Fe3+、Mg2+等其他金属离子的转运蛋白也被证实可通过影响微生物胞内相容性溶质的合成起到渗透调节的作用。本文综述了嗜盐耐盐微生物中抗盐胁迫相关的各类离子转运蛋白,分析其分子结构和工作机理,并对这些蛋白在农业方面的应用进行了展望。继续发现新的离子转运蛋白,探究抗盐胁迫相关离子转运蛋白的结构和机理,解析各转运系统的协同作用及分子调控机制,将进一步加深对嗜盐耐盐微生物抗盐胁迫调控的认识,并为盐碱地农作物的改良等提供新的思路。

    Abstract:

    Ion transporters play an important role in maintaining intracellular pH homeostasis and ionic equilibrium. Sodium ion transporters and potassium ion transporters exist widely in halophilic and halotolerant microorganisms, and their function of retaining potassium and excreting sodium is one of the two major strategies for microbial tolerance to salt stress. In recent years, new sodium and potassium ion transporters, such as RDD, UPF0118, DUF, and KimA, have been discovered in halophilic and halotolerant microorganisms. The transporters of other metal ions, such as Fe3+ and Mg2+, have been proved to play a role in microbial osmoregulation by participating in the synthesis of intracellular compatible solutes. This paper reviews the ion transporters associated with salt stress tolerance in halophilic and halotolerant microorganisms, analyzes their molecular structures and working mechanisms, and prospects for their applications in agriculture. Discovering new ion transporters, revealing the structures and mechanisms of ion transporters associated with salt stress tolerance, and analyzing the synergistic effect of coexisting transporter systems and their regulation mechanisms will deepen the understanding of the regulatory mechanisms of salt stress tolerance of halophilic and halotolerant microorganisms and provide new ideas for the improvement of crops in saline-alkali land.

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马欣,马想蓉,朱德锐,李永臻,邢江娃. 嗜盐耐盐微生物抗盐胁迫相关离子转运蛋白研究进展. 微生物学报, 2024, 64(3): 651-671

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历史
  • 收稿日期:2023-08-17
  • 最后修改日期:2023-11-30
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  • 在线发布日期: 2024-03-18
  • 出版日期: 2024-03-04