细菌金属离子外排系统及金属稳态调控

Bacterial metal ion efflux systems and metal homeostasis

摘要:

铁、铜、锌、锰等金属离子是各类生物体生存和增殖所必需的微量元素,可影响生物体内蛋白酶活性、免疫反应、生理过程和抗感染机制。细菌感染过程中,宿主可通过限制或提高体内环境中金属离子的浓度来抑制细菌增殖,与此同时,细菌进化出各种转运系统以适应宿主体内金属离子水平的变化。由于不同细菌的金属离子外排系统在结构和生化特性上存在变异,它们呈现出独特的金属离子外排模式。本文根据现有文献报道及本团队研究结果,对铁、铜、锌和锰离子的细菌外排系统进行讨论和总结,旨在综述目前对细菌金属离子稳态调控机制研究进展的认识,为深入理解细菌金属稳态调控相关机制提供参考。

Abstract:

Metals like iron, copper, zinc, and manganese are trace elements essential for the survival and growth of diverse organisms. They influence the protease activity, immune response, physiological processes, and anti-infection mechanism in organisms. During bacterial infection, the host can limit or increase the availability of metal ions in the internal environment to inhibit bacterial proliferation. Meanwhile, bacteria have evolved various transport systems to adapt to the changes in metal ion levels in the host. The metal ion efflux systems exhibit distinctive efflux patterns due to variations in the structural and biochemical properties. We reviewed the available articles and our own research findings about the bacterial efflux systems of iron, copper, zinc, and manganese ions, aiming to provide an overview of the progress in the research on the regulatory mechanisms governing bacterial metal homeostasis. This review of metal ion efflux systems across different bacteria highlights the adaptation that enables bacterial survival in diverse host environments.