基于Web of Science的肠道微生物群与代谢综合征全球研究热点与趋势(2005-2024)

Global hotspots and trends in gut microbiota and metabolic syndrome research based on Web of Science (2005-2024)

摘要:

系统分析2005-2024年间肠道微生物群与代谢综合征(metabolic syndrome, MetS)研究的现状和趋势，识别关键研究热点，为后续研究和干预措施提供参考。本文采用Web of Science核心合集数据库，检索并筛选涉及肠道微生物群与MetS的相关文献。利用VOSviewer、CiteSpace及R语言bibliometrix包等文献计量学工具，对文献的发表趋势、国家与机构分布、研究主题和热点等方面进行统计分析。共纳入4 210篇相关文献，年发文量持续增长，2010年后增速显著。中国和美国发文量位居前列，研究成果主要发表在Nutrients、Gut和Nature等期刊；研究热点主要覆盖营养与饮食、生物化学与分子生物学、微生物学等领域；关键词演化分析显示，研究主题已由早期的菌群结构描述转向机制探讨，聚焦于肠道微生物群失调相关的能量代谢、炎症反应及肠-远端器官互作等调控机制。高频关键词共现分析还表明，短链脂肪酸、胆汁酸等关键代谢产物，以及微生物制剂和粪菌移植等微生态干预策略，逐渐成为该领域关注焦点。本研究通过文献计量学系统梳理了肠道微生物群与MetS的研究现状，揭示了研究热点和未来趋势。鉴于传统治疗手段在靶向性、依从性及长期安全性方面仍存在一定局限，靶向肠道菌群的微生态干预有望成为MetS防治的潜在突破口，为未来精准治疗提供了重要理论支撑。

Abstract:

To systematically analyze the current status and research trends and identify the key research hotspots in the field of gut microbiota and metabolic syndrome (MetS) from 2005 to 2024, thus providing references for future research and intervention strategies. Relevant literature on gut microbiota and MetS was retrieved and screened from the Web of Science Core Collection. Bibliometric tools such as VOSviewer, CiteSpace, and the R package bibliometrix were used to analyze the publication trends, countries and institutions, research themes, and emerging hotspots. A total of 4 210 relevant publications were included. The annual number of publications showed an increasing trend, which was particular rapid after 2010. China and the United States led in publication output, and major research findings were published in journals such as Nutrients, Gut, and Nature. Research hotspots primarily covered the fields of nutrition and diet, biochemistry and molecular biology, and microbiology. Keyword evolution analysis revealed a shift from early descriptive studies on gut microbiota composition to mechanism investigations focusing on dysbiosis-related pathways such as energy metabolism, inflammatory responses, and gut-organ axes. Co-occurrence analysis further indicated that key microbial metabolites (e.g., short-chain fatty acids and bile acids) and microbiota-targeted interventions (e.g., probiotics and fecal microbiota transplantation) had become focal points in recent studies. This bibliometric study comprehensively summarizes the research landscape of gut microbiota and MetS and highlights emerging trends and directions. Given the limitations of conventional therapies in terms of targeting specificity, patient adherence, and long-term safety, microbiota-based interventions offer a promising breakthrough for the prevention and treatment of MetS, providing valuable theoretical support for future precision medicine.