氧化应激在猪肠道冠状病毒感染中的作用及相关治疗的研究进展

Research progress in the role of oxidative stress in porcine enteric coronavirus infection and related therapies

摘要:

猪肠道冠状病毒(porcine enteric coronaviruses, PECs)包括猪流行性腹泻病毒(porcine epidemic diarrhea virus, PEDV)、传染性胃肠炎病毒(transmissible gastroenteritis virus, TGEV)和猪δ冠状病毒(porcine deltacoronavirus, PDCoV)。PECs感染会导致猪(尤其是新生仔猪)出现严重腹泻，具有高致死率，给全球养猪业带来重大威胁并造成经济损失。PECs感染会引发氧化应激，进而激活多种转录因子，改变其转录途径，影响细胞代谢和病毒的生命周期，最终导致细胞功能障碍，并进一步促进病毒增殖，形成恶性循环。PECs感染增加的氧化应激被视为潜在的共同病因之一。本文综述了PECs感染引起的相关氧化应激信息，并强调抗氧化是应对PECs感染的有效策略之一。

Abstract:

Porcine enteric coronaviruses (PECs) include porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV). Infections with PECs can cause severe diarrhea in pigs, particularly newborn piglets, resulting in high mortality rates and posing a serious threat and economic loss to the global swine industry. Such infections induce oxidative stress to activate various transcription factors and alter their transcriptional pathways, thereby affecting cellular metabolism and the viral life cycle. This leads to cellular dysfunction and further promotes viral replication, forming a vicious cycle. The oxidative stress associated with PECs is considered one of the potential common pathogenic mechanisms. This review summarizes the information about the oxidative stress induced by infections with PECs and emphasizes that antioxidant strategies represent one of the effective approaches to counteract such infections.