猪链球菌检测技术研究进展

Advances in detection methods for Streptococcus suis

摘要:

猪链球菌(Streptococcus suis)是猪的重要致病菌，能够引发猪的脑膜炎、败血症、关节炎等多种疾病，给养猪业带来严重的经济损失。此外，该菌也能感染人类，导致疾病甚至死亡，是重要的人兽共患病原菌。因此，建立准确、快速、灵敏且简便的检测技术对于猪链球菌病的防控至关重要。目前，国内外已开发出多种猪链球菌检测技术，包括传统的微生物学、分子生物学、免疫学方法，以及基于纳米材料的免疫传感器、CRISPR-Cas12a系统、基质辅助激光解吸/电离飞行时间质谱等新型检测技术。本综述概述了上述技术的原理、应用及其优缺点，并探讨了猪链球菌检测技术未来的发展方向，旨在为猪链球菌病的防控提供重要参考。

Abstract:

Streptococcus suis, a major pathogen of pigs, can cause meningitis, septicemia, and arthritis, leading to serious economic losses in the pig industry. In addition, it can also infect humans and result in diseases or death, being a zoonotic pathogen. Therefore, accurate, rapid, sensitive, and simple detection methods are critical for the prevention and control of swine streptococcosis. At present, a variety of detection methods for S. suis have been developed, including traditional detection methods of microbiology, molecular biology, and immunology and emerging technologies such as nanomaterial-based immunosensors, CRISPR-Cas12a system, and matrix-assisted laser desorption ionization-time of flight mass spectrometry. This review summarizes the principles, applications, advantages, and disadvantages of the above methods and introduces the future directions of S. suis detection methods, aiming to provide reference for the prevention and control of swine streptococcosis.