蛋白质甲基化修饰对视黄酸诱导基因I样受体家族信号通路分子调控作用

Molecular regulation of the retinoic acid-inducible gene-I -like receptor signaling pathway by protein methylation

摘要:

RNA病毒的暴发流行严重威胁人类健康。视黄酸诱导基因I (retinoic acid-inducible gene-I, RIG-I)样受体家族(RIG-I-like receptors, RLRs)信号通路在宿主抵抗病毒感染过程中发挥着重要作用。RLRs能够识别病毒入侵后产生的RNA，启动RLR信号通路的激活，从而对抗病毒感染。然而，RLR信号通路的异常激活会导致慢性炎症、免疫器官损伤以及自身免疫性疾病。为了防止RLR信号通路激活的紊乱，机体建立了完善的调节系统来稳定RLR信号通路。蛋白质甲基化修饰是一种重要的蛋白质翻译后修饰方式，在众多生物过程中发挥着重要作用。RLR信号通路分子的蛋白质甲基化修饰已被证明对机体调控RLR信号通路至关重要。因此，本文综述蛋白质甲基化修饰对RLR信号通路分子调控作用的研究进展，为宿主调控抗病毒RLR信号通路提供新的见解。

Abstract:

Outbreaks and epidemics of RNA viruses represent a serious threat to human health. The retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs) signaling pathway plays a pivotal role in host resistance to viral infections. RLRs recognize the RNA produced after viral invasion, initiating the activation of the RLR signaling pathway to combat viral infection. Abnormal activation of this pathway is linked to the development of chronic inflammation, damage to immune organs, and autoimmune diseases. To prevent the disruption of RLR signaling pathway activation, the body has established a comprehensive regulatory system with the objective of stabilizing the RLR signaling pathway. Protein methylation represents a significant post-translational modification of proteins, playing a pivotal role in numerous biological processes. The methylation of molecules in the RLR signaling pathway has been demonstrated to be indispensable for the body to regulate the RLR signaling pathway. This paper presents a comprehensive review of the latest research findings on the role of protein methylation in regulation of the RLR signaling pathway, offering novel insights into the host regulation of the RLR signaling pathway in combatting viral infection.