流体剪切力介导的变异链球菌生物膜形成机制研究进展

Research progress on the mechanism of biofilm formation of Streptococcus mutans mediated by fluid shear stress

摘要:

本文系统分析了流体剪切力对变异链球菌生物膜形成的动态调控，阐明了其在致病机制中的核心作用，并为龋病防治提供了新策略。变异链球菌是口腔内主要的致龋菌，它通过形成生物膜并代谢产酸来破坏牙体组织。研究表明，流体剪切力能够调节生物膜的物理结构、胞外聚合物的分泌、黏附能力以及群体感应系统，从而影响其致病性。本研究为深入理解病原菌在流体环境中的生态适应性，以及开发新的临床干预措施提供了理论依据。

Abstract:

This article explores the dynamic regulation of fluid shear stress on the biofilm formation of Streptococcus mutans, aiming to elucidate the pathogenic mechanism of this bacterium and provide references for the prevention of dental caries. S. mutans is a major cariogenic bacterium in the oral cavity, and it destroys the tooth tissue by forming biofilms and producing acids by metabolism. Studies have shown that fluid shear stress can regulate the physical structure, secretion of extracellular polymeric substances, adhesion, and quorum sensing of biofilms, thereby affecting the pathogenicity. This study provides a theoretical basis for deeply understanding the ecological adaptability of pathogens in fluid environments and the development of new intervention measures in clinical practice.