热休克蛋白8影响病毒感染宿主细胞的研究进展

Research progress on the impact of heat shock protein family A member 8 on virus infection of host cells

摘要:

热休克蛋白8 (heat shock protein family A member 8, HSPA8)是一种广泛存在于细胞内的分子伴侣蛋白。该蛋白参与多项细胞生理过程，主要包括蛋白质的正确折叠与转运、应激反应、抗原蛋白呈递、自噬介导以及免疫调控等，对维持细胞内环境稳态至关重要。此外，HSPA8在病毒感染的多个过程中发挥关键作用。本文综述了HSPA8在病毒黏附、病毒糖蛋白-受体复合物形成、内化、脱壳、基因组复制、组装，以及调节宿主代谢和免疫反应等过程中所发挥的重要作用及其分子机制，为后续靶向HSPA8的抗病毒药物研发奠定了基础。

Abstract:

Heat shock protein family A member 8 (HSPA8) is a widely distributed molecular chaperone in cells. HSPA8 is involved in multiple cellular physiological processes, mainly including the correct folding and transport of proteins, stress responses, presentation of antigenic proteins, mediation of autophagy, and immune regulation. It is also crucial for maintaining the homeostasis of the intracellular environment. In addition, HSPA8 plays a key role in multiple processes of virus infections. This paper reviewed the important roles and molecular mechanisms of HSPA8 in processes such as virus adhesion, formation of virus glycoprotein-receptor complexes, internalization, uncoating, genome replication, assembly, and regulation of host metabolism and immune responses, with the hope of laying a foundation for the subsequent development of drugs targeting HSPA8 for the treatment of virus infections.