2025年3月18日 周二
首页 > 过刊浏览>2025年第65卷第3期 >916-938. DOI:10.13343/j.cnki.wsxb.20240640
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莽草酸的生物合成研究进展
作者:
作者单位:

福建师范大学 生命科学学院，工业微生物发酵技术国家地方联合工程研究中心，工业微生物教育部工程中心，福建 福州

作者简介:

夏煌慧：负责文章总体框架的确定、数据的收集与整理，并负责论文的初稿撰写与修订工作；崔树梅：负责研究设计、数据收集；黄建忠：负责写作指导。

基金项目:

国家重点研发计划(2022YFD1802104)


Research progress in shikimic acid biosynthesis
Author:
  • XIA Huanghui

    XIA Huanghui

    Engineering Research Center of Industrial Microbiology, Ministry of Education, National and Local United Engineering Research Center of Industrial Microbiology and Fermentation Technology, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, China
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  • CUI Shumei

    CUI Shumei

    Engineering Research Center of Industrial Microbiology, Ministry of Education, National and Local United Engineering Research Center of Industrial Microbiology and Fermentation Technology, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, China
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  • HUANG Jianzhong

    HUANG Jianzhong

    Engineering Research Center of Industrial Microbiology, Ministry of Education, National and Local United Engineering Research Center of Industrial Microbiology and Fermentation Technology, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, China
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Affiliation:

Engineering Research Center of Industrial Microbiology, Ministry of Education, National and Local United Engineering Research Center of Industrial Microbiology and Fermentation Technology, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, China

Fund Project:

This work was supported by the National Key Research and Development Program of China (2022YFD1802104).

  • 摘要
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  • 访问统计
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  • 参考文献 [116]
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  • 相似文献 [20]
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    摘要:

    莽草酸(shikimic acid, SA)是一种重要的天然化合物，在生物体内具有抗病毒、抗血栓、镇痛、抑菌、抑制恶性肿瘤等多重功能，广泛应用于医药、化妆品、食品和农业等领域，因此被视为是极具潜力的生物分子。作为芳香族化合物的前体，莽草酸在生物体内的代谢途径中起着重要作用。传统的莽草酸生产方式主要依赖于从植物(如八角茴香)中提取或通过化学合成，这些方法不仅成本高、效率低，还对环境造成负担。随着合成生物学和代谢工程技术的不断进步，利用生物代谢工程技术生产莽草酸因其更高的可持续性和经济性，逐渐成为研究热点。本文综述了莽草酸的应用领域及其生产方法，并重点阐述了其生物合成的研究进展与优化策略。

    Abstract:

    Shikimic acid (SA) is an important natural compound with many biological activities, including antiviral, antithrombotic, analgesic, antimicrobial, and anti-cancer properties. Due to its diverse applications in medicine, cosmetics, food, and agriculture, SA is considered a highly promising biomolecule. As a precursor of aromatic compounds, SA plays a crucial role in various metabolic pathways within organisms. Traditional methods for producing SA mainly rely on plant extraction (such as star anise) or chemical synthesis. However, these approaches face challenges such a high costs, low efficiency, and environmental concerns. With the ongoing advancements in synthetic biology and metabolic engineering, the production of SA through metabolic engineering has emerged as a focal point of research, offering a more sustainable and cost-effective alternative. This paper reviews the applications and production methods of SA, with a particular emphasis on recent progress and optimization strategies in its biosynthesis.

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夏煌慧,崔树梅,黄建忠. 莽草酸的生物合成研究进展[J]. 微生物学报, 2025, 65(3): 916-938

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