真菌凋亡样细胞死亡和靶向药物的研究进展
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黑龙江大学 生命科学学院,农业微生物技术教育部工程研究中心,黑龙江省寒区植物基因与生物发酵重点 实验室,黑龙江省普通高校微生物重点实验室,黑龙江 哈尔滨

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王柳茜:绘制图片以及文章的撰写和整理;李珑捷:绘制图片以及参与论文选题讨论;田庆庆:文献收集及整理;杜春梅:论文选题、撰写、修改和审阅。

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国家自然科学基金(32172468)


Advances in fungal apoptosis-like cell death and targeted drugs
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Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education, Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold Region, Key Laboratory of Microbiology in Colleges and Universities of Heilongjiang Province, School of Life Science, Heilongjiang University, Harbin, Heilongjiang, China

Fund Project:

This work was supported by the National Natural Science Foundation of China (32172468).

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    摘要:

    目前,治疗真菌感染的药物数量有限且已产生脱靶效应,研发新型抗真菌药物迫在眉睫。真菌凋亡样细胞死亡(apoptosis-like cell death, ALCD)是生物体在正常发育阶段细胞发生的死亡现象。本文概述了真菌ALCD的特征、所涉及的信号通路及关键因子,介绍了可诱导真菌凋亡的天然药物和人工合成药物。其中,天然药物包括来自微生物源的脂肽、法尼醇、他汀类、生物碱,来自植物源的有机酸、精油,以及来自昆虫的蜂毒素,并绘制了药物诱导真菌ALCD的基础分子景观。本文为制定新的抗病原真菌策略和研发靶向抗真菌药物提供了理论依据。

    Abstract:

    Currently, the drugs available for treating fungal infections show limited number and off-target effects. Thus, there is an urgent need to develop new antifungal drugs. Fungal apoptosis-like cell death (ALCD) is a cell death phenomenon that occurs during the normal development stage of organisms. This article summarizes the characteristics, signaling pathways, and key factors involved in fungal ALCD and introduces the natural and synthetic drugs that can induce fungal apoptosis. The natural drugs include lipid peptides, farnesol, statins, and alkaloids from microorganisms, organic acids and essential oils from plants, and melittins from insects. Furthermore, this article establishes the basic molecular landscape of drug-induced fungal ALCD. This article provides a theoretical basis for formulating a new strategy for resisting pathogenic fungi and developing targeted antifungal drugs.

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王柳茜,李珑捷,田庆庆,杜春梅. 真菌凋亡样细胞死亡和靶向药物的研究进展[J]. 微生物学报, 2025, 65(7): 2811-2829

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  • 收稿日期:2024-12-19
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  • 在线发布日期: 2025-07-04
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