畜禽疾病中铁死亡的发生和作用机制

Occurrence and mechanism of ferroptosis in livestock and poultry diseases

摘要:

铁死亡(ferroptosis)是一种新型程序性细胞死亡形式，以铁依赖性脂质过氧化损伤为主要危害特征。铁死亡与多种疾病的发生发展密切相关，多种病原被证实通过诱导宿主细胞铁死亡，促进自身增殖，拮抗宿主免疫等，广泛参与病原感染所致的病理生理学过程。多种代谢病、中毒病等的病理过程中也存在铁死亡的参与。本文就畜禽疾病中的铁死亡现象及作用机制的研究进展进行综述，以期为进一步探索铁死亡参与畜禽疾病的作用及机制提供参考。

关键词:铁死亡;畜禽疾病;宿主细胞;致病机制

Abstract:

Ferroptosis is a novel form of programmed cell death that is iron-dependent and primarily characterized by lipid peroxidation. Studies have indicated that ferroptosis is closely related to the occurrence and development of various diseases. A variety of pathogens have been confirmed to induce ferroptosis of host cells, which facilitates pathogen proliferation and counteracting host immunity. Therefore, ferroptosis extensively participates in the pathophysiological processes caused by pathogen infection. In addition, ferroptosis is involved in the pathological process of many metabolic and poisoning diseases. This paper reviews the research progress in the occurrence and mechanism of ferroptosis in livestock and poultry diseases, aiming to provide reference for further exploring the effect and mechanism of ferroptosis in livestock and poultry diseases.

Key words:ferroptosis;livestock and poultry diseases;host cell;pathogenesis