2025年7月25日 周五
首页 > 过刊浏览>2025年第65卷第1期 >52-61. DOI:10.13343/j.cnki.wsxb.20240540
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畜禽疾病中铁死亡的发生和作用机制
作者:
基金项目:

国家生猪技术创新中心项目(NCTIP-XDIC17);重庆市现代农业产业技术体系(CQMAITS202312);中央高校基本科研业务费专项资金(SWU-KQ22051);重庆市高校创新研究群体(CXQT20004);重庆市技术创新与应用发展专项(CSTB2023TIAD-LDX0024)


Occurrence and mechanism of ferroptosis in livestock and poultry diseases
Author:
  • LEI Di

    LEI Di

    Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China;Chongqing Collaborative Innovation Research Institute, National Center of Technology Innovation for Pigs, Chongqing 402460, China
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  • XU Boyi

    XU Boyi

    Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China;Chongqing Collaborative Innovation Research Institute, National Center of Technology Innovation for Pigs, Chongqing 402460, China
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  • FANG Rendong

    FANG Rendong

    Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China;Chongqing Collaborative Innovation Research Institute, National Center of Technology Innovation for Pigs, Chongqing 402460, China
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  • WANG Hongzhi

    WANG Hongzhi

    Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China;Chongqing Collaborative Innovation Research Institute, National Center of Technology Innovation for Pigs, Chongqing 402460, China
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  • 摘要
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    摘要:

    铁死亡(ferroptosis)是一种新型程序性细胞死亡形式，以铁依赖性脂质过氧化损伤为主要危害特征。铁死亡与多种疾病的发生发展密切相关，多种病原被证实通过诱导宿主细胞铁死亡，促进自身增殖，拮抗宿主免疫等，广泛参与病原感染所致的病理生理学过程。多种代谢病、中毒病等的病理过程中也存在铁死亡的参与。本文就畜禽疾病中的铁死亡现象及作用机制的研究进展进行综述，以期为进一步探索铁死亡参与畜禽疾病的作用及机制提供参考。

    Abstract:

    Ferroptosis is a novel form of programmed cell death that is iron-dependent and primarily characterized by lipid peroxidation. Studies have indicated that ferroptosis is closely related to the occurrence and development of various diseases. A variety of pathogens have been confirmed to induce ferroptosis of host cells, which facilitates pathogen proliferation and counteracting host immunity. Therefore, ferroptosis extensively participates in the pathophysiological processes caused by pathogen infection. In addition, ferroptosis is involved in the pathological process of many metabolic and poisoning diseases. This paper reviews the research progress in the occurrence and mechanism of ferroptosis in livestock and poultry diseases, aiming to provide reference for further exploring the effect and mechanism of ferroptosis in livestock and poultry diseases.

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雷迪,徐博艺,方仁东,王鸿志. 畜禽疾病中铁死亡的发生和作用机制[J]. 微生物学报, 2025, 65(1): 52-61

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  • 收稿日期:2024-09-01
  • 在线发布日期: 2025-01-04
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