嗜黏蛋白阿克曼氏菌与糖脂代谢研究进展

Research progress in Akkermansia muciniphila and glucose and lipid metabolism

摘要:

嗜黏蛋白阿克曼氏菌(Akkermansia muciniphila, AKK)作为一种重要的肠道微生物，近年来在糖脂代谢及其调节机制方面引起了广泛关注。糖脂代谢紊乱是由多种因素引起的，表现为高血糖、血脂异常等问题，这种疾病不仅在全球范围内广泛流行，也在我国年轻人中越来越普遍，成为公共卫生的重要问题。因此，本综述从AKK的作用机制出发，系统阐述了AKK与糖脂代谢的相关研究进展，并分别从AKK对糖代谢和脂代谢的调节机制、药物增加AKK的丰度对糖脂代谢的影响，以及AKK的工程改造研究等方面进行综述。通过对现有文献的综合分析，为研究糖脂代谢紊乱及治疗相关疾病提供了有价值的参考和启示。

Abstract:

Akkermansia muciniphila, a major gut microorganism, has garnered significant attention for its involvement in the regulation of glucose and lipid metabolism. Glucose and lipid metabolic disorders, characterized by hyperglycemia and dyslipidemia, are caused by multiple factors. These disorders are not only prevalent globally but also increasingly common among young people in China, representing a major public health concern. This review systematically elaboratesthe research progress in A. muciniphila and glucose and lipid metabolism from the perspective of its mechanisms of action. Specifically, the review summarizes the regulatory pathways through which A. muciniphila influence glucose and lipid metabolism, assesses how pharmaceuticals that enhance A. muciniphila abundance affect metabolic parameters, and discusses advances in the bioengineering of A. muciniphila. By synthesizing current research findings, this review aims to provide valuable insights for understanding glucose and lipid metabolic disorders and developing novel therapeutic approaches for related diseases.