高原环境下皮肤微生物群对皮肤病影响的研究进展
作者:
作者单位:

1.青海民族大学 药学院,青海 西宁;2.苏州大学附属第二医院 药学部,江苏 苏州

作者简介:

白雪:全文撰写、绘图并核对论文内容;杨建鑫:对论文进行整体的指导和修改。

基金项目:

苏州大学附属第二医院科研预研基金(SDFEYBS2308);苏州大学附属第二医院学科建设托举项目(XKTJ-XK202406)


Research progress in the effects of skin microbiota on skin diseases in plateau environments
Author:
Affiliation:

1.College of Pharmacy, Qinghai Minzu University, Xining, Qinghai, China;2.Department of Pharmacy, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China

Fund Project:

This work was supported by the Second Affiliated Hospital of Soochow University Pre-research Fund (SDFEYBS2308) and the Second Affiliated Hospital of Soochow University Discipline Building Project (XKTJ-XK202406).

  • 摘要
  • | |
  • 访问统计
  • |
  • 参考文献 [82]
  • |
  • 相似文献 [20]
  • | | |
  • 文章评论
    摘要:

    高原特殊环境下,机体皮肤会出现一系列适应性反应和病理性变化,这些变化包括皮肤屏障功能受损、皮肤血管收缩障碍、角质层异常增厚、纤维素沉积等,导致高原地区皮肤疾病的发病率相对较高。研究表明,高原环境中皮肤微生物的组成和多样性会发生变化,这可能与皮肤疾病的发生、发展密切相关。本文旨在综述高原环境对皮肤的影响、高原常见皮肤病,以及微生物对皮肤疾病的影响,并探讨高原环境下皮肤微生物群对皮肤疾病的影响及作用机制。

    Abstract:

    In the special environment of plateau, adaptive responses and pathological changes occur in the skin of organisms, which include skin barrier dysfunction, skin vasoconstriction disorder, abnormal thickening of the stratum corneum, and fibrous pigment deposition, leading to a high incidence of skin diseases in plateau areas. In the plateau environment, the composition and diversity of skin microbiota change, which may be related to the occurrence and development of skin diseases. This paper reviews the effects of plateau environments on the skin, common skin diseases in plateau environments, and the effects of skin microbiota on skin diseases and discusses the mechanisms by which skin microbiota influences skin diseases in plateau environments.

    参考文献
    [1] 吴天一. 吴天一高原医学[M]. 武汉: 湖北科学技术出版社, 2020: 1-225.WU TY. Wu Tianyi High Altitude Medicine[M]. Wuhan: Hubei Science and Technology Press, 2020: 1-225 (in Chinese).
    [2] 杨建鑫. 高原低氧条件下HNF1α与HNF4α对CYP450的转录调控[D]. 西宁: 青海大学博士学位论文, 2023.YANG JX. Transcriptional regulation of HNF1α and HNF4α on CYP450 under high-altitude hypoxia[D]. Xining: Doctoral Dissertation of Qinghai University, 2023 (in Chinese).
    [3] 曹馨予. 低氧暴露对汗液分泌的影响及其作用机制的初步研究[D]. 西安: 中国人民解放军空军军医大学硕士学位论文, 2024.CAO YX. A preliminary study on the effect of hypoxic exposure on sweat secretion and its mechanism[D]. Xi’an: Master’s Thesis of Air Force Medical University, 2024 (in Chinese).
    [4] HARRIS-TRYON TA, GRICE EA. Microbiota and maintenance of skin barrier function[J]. Science, 2022, 376(6596): 940-945.
    [5] FOURNIèRE M, LATIRE T, SOUAK D, FEUILLOLEY MGJ, BEDOUX G. Staphylococcus epidermidis and Cutibacterium acnes: two major sentinels of skin microbiota and the influence of cosmetics[J]. Microorganisms, 2020, 8(11): 1752.
    [6] 刘祎. 人类皮肤微生物参考基因目录及高原成年人皮肤微生物景观描绘[D]. 上海: 中国人民解放军海军军医大学硕士学位论文, 2023.LIU Y. Directory of reference genes of human skin microorganisms and description of skin microbial landscape of plateau adults[D]. Shanghai: Master’s Thesis of Naval Medical University, 2023 (in Chinese).
    [7] 格日力. 高原医学[M]. 北京: 北京大学医学出版社, 2015: 1-10.GE RL. High Altitude Medicine[M]. Beijing: Peking University Medical Press, 2015: 1-10 (in Chinese).
    [8] 高钰琪. 高原军事医学[M]. 重庆: 重庆出版社, 2005: 373-385.GAO YQ. Gao Yuan Jun Shi Yi Xue[M]. Chongqing: Chongqing Publishing & Media Co., Ltd., 2005: 373-385 (in Chinese).
    [9] 李莲, 张禁. 高原特勤人员皮肤病防治研究进展[J]. 武警医学, 2022, 33(9): 821-823.LI L, ZHANG J. Research progress on prevention and treatment of dermatosis in plateau secret service personnel[J]. Medical Journal of the Chinese People’s Armed Police Force, 2022, 33(9): 821-823 (in Chinese).
    [10] 李勇坚. 银屑病皮损及缺氧条件下HaCaT细胞HIF-1α与血管生成相关蛋白表达关系的研究[D]. 长沙: 中南大学博士学位论文, 2010.LI YJ. Study on the relationship between HIF-1α and angiogenesis-related protein expression in HaCaT cells under psoriasis lesions and hypoxia[D]. Changsha: Doctoral Dissertation of Central South University, 2010 (in Chinese).
    [11] 陈宇杰. 角质形成细胞调节性细胞死亡在紫外线诱发的皮肤炎症中的作用研究[D]. 北京: 北京协和医学院博士学位论文, 2023.CHEN YJ. Study on the role of keratinocyte regulatory cell death in ultraviolet-induced skin inflammation[D]. Beijing: Doctoral Dissertation of Peking Union Medical College, 2023 (in Chinese).
    [12] TODOROVA K, MANDINOVA A. Novel approaches for managing aged skin and nonmelanoma skin cancer[J]. Advanced Drug Delivery Reviews, 2020, 153: 18-27.
    [13] SHIN N, LEE SH, CHO Y, PARK TH, HONG S. Bioelectronic skin based on nociceptive ion channel for human-like perception of cold pains[J]. Small, 2020, 16(30): e2001469.
    [14] HOSEINZADEH E, TAHA P, WEI CA, GODINI H, ASHRAF GM, TAGHAVI M, MIRI M. The impact of air pollutants, UV exposure and geographic location on vitamin D deficiency[J]. Food and Chemical Toxicology, 2018, 113: 241-254.
    [15] BATTIE C, JITSUKAWA S, BERNERD F, del BINO S, MARIONNET C, VERSCHOORE M. New insights in photoaging, UVA induced damage and skin types[J]. Experimental Dermatology, 2014, 23(Suppl 1): 7-12.
    [16] ZASTROW L, GROTH N, KLEIN F, KOCKOTT D, LADEMANN J, RENNEBERG R, FERRERO L. The missing link: light-induced (280-1, 600 nm) free radical formation in human skin[J]. Skin Pharmacology and Physiology, 2009, 22(1): 31-44.
    [17] De GRUIJL FR. UV adaptation: pigmentation and protection against overexposure[J]. Experimental Dermatology, 2017, 26(7): 557-562.
    [18] 李辉,周文. 124例高原神经性皮炎的治疗体会[J]. 大家健康(学术版), 2013, 7(18): 101-102.LI H, ZHOU W. Treatment of 124 cases of plateau neurodermatitis[J]. For all Health, 2013, 7(18):101-102 (in Chinese).
    [19] 汉瑞娟, 李娟, 朱鑫华, 陆皓. 高原日光性皮炎防护研究进展[J]. 解放军护理杂志, 2016, 33(17): 45-46.HAN RJ, LI J, ZHU XH, LU H. Advances in the study of protection against solar dermatitis in the highlands[J]. Military Nursing, 2016, 33(17): 45-46 (in Chinese).
    [20] 杨维玲, 张继刚, 张重军, 王玉真. 某驻藏部队官兵皮肤病患病情况调查分析[J]. 人民军医, 2013, 56(4): 376-377.YANG WL, ZHANG JG, ZHANG CJ, WANG YZ. Investigation and analysis of dermatosis in officers and men of a certain army stationed in Xizang[J]. People’s Military Surgeon, 2013, 56(4): 376-377 (in Chinese).
    [21] 徐晴, 赵芸珂, 孙敏, 余玲, 刘红梅, 肖蓉. 不同海拔高原日光照射对正常藏族人群皮肤弹性的影响[J]. 中国医学影像技术, 2022, 38(4): 516-519.XU Q, ZHAO YK, SUN M, YU L, LIU HM, XIAO R. Impacts of different altitudes sunlight on skin elasticity of normal Tibetan population[J]. Chinese Journal of Medical Imaging Technology, 2022, 38(4): 516-519 (in Chinese).
    [22] 金媛媛. 刺五加糖蛋白对紫外线引起的皮肤光老化的修复作用及机制研究[D]. 长春: 长春中医药大学博士学位论文, 2022.JIN YY. Study on the repair effect and mechanism of Acanthopanax senticosus glycoprotein on ultraviolet-induced skin photoaging[D]. Changchun: Doctoral Dissertation of Changchun University of Chinese Medicine, 2022 (in Chinese).
    [23] JANSEN MHE, KESSELS JPHM, NELEMANS PJ, KOULOUBIS N, ARITS AHMM, van PELT HPA, QUAEDVLIEG PJF, ESSERS BAB, STEIJLEN PM, KELLENERS-SMEETS NWJ, MOSTERD K. Randomized trial of four treatment approaches for actinic keratosis[J]. New England Journal of Medicine, 2019, 380(10): 935-946.
    [24] DOW J, GIESBRECHT GG, DANZL DF, BRUGGER H, SAGALYN EB, WALPOTH B, AUERBACH PS, McINTOSH SE, NéMETHY M, McDEVITT M, SCHOENE RB, RODWAY GW, HACKETT PH, ZAFREN K, BENNETT BL, GRISSOM CK. Wilderness medical society clinical practice guidelines for the out-of-hospital evaluation and treatment of accidental hypothermia: 2019 update[J]. Wilderness & Environmental Medicine, 2019, 30(4S): S47-S69.
    [25] 王园园, 邢微微, 付文亮, 徐东刚. 高原部队常见皮肤病及防治[J]. 军事医学, 2020, 44(6): 470-474.WANG YY, XING WW, FU WL, XU DG. Clinical manifestations and prevention of common dermatoses among plateau troops[J]. Military Medical Sciences, 2020, 44(6): 470-474 (in Chinese).
    [26] 马新苹. 冬病夏治隔姜灸治疗女性手部Ⅰ、Ⅱ度冻疮的临床观察[D]. 成都: 成都中医药大学硕士学位论文, 2013.MA XP. Clinical observation of ginger moxibustion treatment of female Ⅰ, Ⅱ degree hand Chilblain of treating winter diseases in summer[D]. Chengdu: Master’s Thesis of Chengdu University of TCM, 2013 (in Chinese).
    [27] 张婧. 富血小板血浆对兔冻伤创面影响的实验研究[D]. 南充: 川北医学院硕士学位论文, 2023.ZHANG J. Experimental study on the effects of PRP on frostbite wound of rabbits[D]. Nanchong: Master’s Thesis of North Sichuan Medical College, 2023 (in Chinese).
    [28] PERSITZ J, ESSA A, NER EB, ASSARAF E, AVISAR E. Frostbite of the extremities-recognition, evaluation and treatment[J]. Injury, 2022, 53(10): 3088-3093.
    [29] YANG ZR, LIU JY, LI FZ, YAN PH, LIU YM, SUN FR. Effect of acute hypoxia and hypoxic acclimation on hemorheological behavior in rats with frostbite[J]. Clinical Hemorheology and Microcirculation, 1999, 20(3): 189-195.
    [30] HU J, LI H, GENG XL, JIAO L, SONG HP, LOU L, JIAO MK. Pathophysiologic determination of frostbite under high altitude environment simulation in sprague-dawley rats[J]. Wilderness & Environmental Medicine, 2016, 27(3): 355-363.
    [31] 刘嘉瀛, 张智勇, 杨增仁, 李凤芝, 颜培华, 刘友梅. 冷冻和缺氧对大鼠血清肌酸激酶活性的影响[J]. 航天医学与医学工程, 1996, 9(4): 291-294.LIU JY, ZHANG ZY, YANG ZR, LI FZ, YAN PH, LIU YM. Effects of freezing and hypoxia on serum creatine kinase activity in rats[J]. Space Medicine & Medical Engineering, 1996, 9(4): 291-294 (in Chinese).
    [32] DAANEN HA, van RUITEN HJ. Cold-induced peripheral vasodilation at high altitudes: a field study[J]. High Altitude Medicine & Biology, 2000, 1(4): 323-329.
    [33] 刘莉. 高原某部新兵身体状况和膳食营养调查研究[D]. 西安: 第四军医大学硕士学位论文, 2013.LIU L. Investigation and study on physical condition and dietary nutrition of recruits in a certain unit of plateau[D]. Xi’an: Master’s Thesis of The Fourth Military Medical University, 2013 (in Chinese).
    [34] 郑婷. 急进高原部队特需药品保障现状及对策研究[D]. 重庆: 第三军医大学硕士学位论文, 2014.ZHENG T. Study on the present situation and countermeasures of special drug support for troops entering the plateau rapidly[D]. Chongqing: Master’s Thesis of Third Military Medical University, 2014 (in Chinese).
    [35] 李姗姗, 聂舒, 吕婷, 张洁尘, 王宏伟. 皮肤干燥症研究进展[J]. 中国皮肤性病学杂志, 2019, 33(5): 599-603.LI SS, NIE S, Lü T, ZHANG JC, WANG HW. Advances in xerosis cutis[J]. The Chinese Journal of Dermatovenereology, 2019, 33(5): 599-603 (in Chinese).
    [36] CABEZAS JE, CABEZAS M, URE?A-LóPEZ V, LAFUENTE LV, MéNDEZ-FLORES KM, LUNA JF, MI?O C, PALACIOS-ALVAREZ SA. Dermoscopic evaluation of actinic changes in the lips of indigenous children living at high altitude in Ecuador: a descriptive study[J]. Medical Science Monitor, 2023, 29: e942554.
    [37] 白雪. 高原低氧环境肠道菌群对CYP450和药物转运体的调节作用[D]. 西宁: 青海大学博士学位论文, 2023.BAI X. Regulation of CYP450 and drug transporter on gut microbiota under high-altitude hypoxia[D]. Xining: Doctoral Dissertation of Qinghai University, 2023 (in Chinese).
    [38] SFRISO R, EGERT M, GEMPELER M, VOEGELI R, CAMPICHE R. Revealing the secret life of skin-with the microbiome you never walk alone[J]. International Journal of Cosmetic Science, 2020, 42(2): 116-126.
    [39] FINDLEY K, OH J, YANG J, CONLAN S, DEMING C, MEYER JA, SCHOENFELD D, NOMICOS E, PARK M, NIH INTRAMURAL SEQUENCING CENTER COMPARATIVE SEQUENCING PROGRAMH, KONG HH, SEGRE JA. Topographic diversity of fungal and bacterial communities in human skin[J]. Nature, 2013, 498(7454): 367-370.
    [40] CUNDELL AM. Microbial ecology of the human skin[J]. Microbial Ecology, 2018, 76(1): 113-120.
    [41] HANNIGAN GD, MEISEL JS, TYLDSLEY AS, ZHENG Q, HODKINSON BP, SanMIGUEL AJ, MINOT S, BUSHMAN FD, GRICE EA. The human skin double-stranded DNA virome: topographical and temporal diversity, genetic enrichment, and dynamic associations with the host microbiome[J]. mBio, 2015, 6(5): e01578-15.
    [42] ERSANLI C, TZORA A, VOIDAROU CC, SKOUFOS S, ZEUGOLIS DI, SKOUFOS I. Biodiversity of skin microbiota as an important biomarker for wound healing[J]. Biology, 2023, 12(9): 1187.
    [43] PISTONE D, MERONI G, PANELLI S, D’AURIA E, ACUNZO M, PASALA AR, ZUCCOTTI GV, BANDI C, DRAGO L. A journey on the skin microbiome: pitfalls and opportunities[J]. International Journal of Molecular Sciences, 2021, 22(18): 9846.
    [44] KALAN LR, MEISEL JS, LOESCHE MA, HORWINSKI J, SOAITA I, CHEN XX, UBEROI A, GARDNER SE, GRICE EA. Strain- and species-level variation in the microbiome of diabetic wounds is associated with clinical outcomes and therapeutic efficacy[J]. Cell Host & Microbe, 2019, 25(5): 641-655.e5.
    [45] GRICE EA, SEGRE JA. The skin microbiome[J]. Nature Reviews Microbiology, 2011, 9(4): 244-253.
    [46] ZHENG YM, LIANG HY, LI ZY, TANG M, SONG LY. Skin microbiome in sensitive skin: the decrease of Staphylococcus epidermidis seems to be related to female lactic acid sting test sensitive skin[J]. Journal of Dermatological Science, 2020, 97(3): 225-228.
    [47] 张盼,伦文辉. 皮肤微生物与皮肤疾病的研究进展[J]. 中国医学前沿杂志(电子版), 2024, 16(1): 17-20.ZHANG P, LUN WH. Research advances in skin microbes and skin disease[J]. Chinese Journal of the Frontiers of Medical Science (Electronic Version), 2024, 16(1): 17-20 (in Chinese).
    [48] 庞梦茹. 皮肤表面微生物菌群结构变化与糖尿病皮肤病变的相关性研究[D]. 广州: 南方医科大学硕士学位论文, 2020.PANG MR. The dynamic changes of the microbiome on the skin surface of diabetic[D]. Guangzhou: Master’s Thesis of Southern Medical University, 2020 (in Chinese).
    [49] NAKATSUJI T, CHIANG HI, JIANG SB, NAGARAJAN H, ZENGLER K, GALLO RL. The microbiome extends to subepidermal compartments of normal skin[J]. Nature Communications, 2013, 4: 1431.
    [50] 刘祎, 杜明威, 何海洋, 朱星睿, 廖万清, 潘炜华. 皮肤微生态强化皮肤屏障功能[J]. 中国皮肤性病学杂志, 2023, 37(11): 1217-1221.LIU Y, DU MW, HE HY, ZHU XR, LIAO WQ, PAN WH. Skin microecology strengthens skin barrier function[J]. The Chinese Journal of Dermatovenereology, 2023, 37(11): 1217-1221 (in Chinese).
    [51] BAY L, BARNES CJ, FRITZ BG, THORSEN J, RESTRUP MEM, RASMUSSEN L, S?RENSEN JK, HESSELVIG AB, ODGAARD A, HANSEN AJ, BJARNSHOLT T. Universal dermal microbiome in human skin[J]. mBio, 2020, 11(1): e02945-19.
    [52] BYRD AL, BELKAID Y, SEGRE JA. The human skin microbiome[J]. Nature Reviews Microbiology, 2018, 16(3): 143-155.
    [53] STAUDINGER T, PIPAL A, REDL B. Molecular analysis of the prevalent microbiota of human male and female forehead skin compared to forearm skin and the influence of make-up[J]. Journal of Applied Microbiology, 2011, 110(6): 1381-1389.
    [54] COSTELLO EK, LAUBER CL, HAMADY M, FIERER N, GORDON JI, KNIGHT R. Bacterial community variation in human body habitats across space and time[J]. Science, 2009, 326(5960): 1694-1697.
    [55] FIERER N, HAMADY M, LAUBER CL, KNIGHT R. The influence of sex, handedness, and washing on the diversity of hand surface bacteria[J]. Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(46): 17994-17999.
    [56] 王逸洁. 24名中国和巴基斯坦大学生皮肤微生物组研究[D]. 兰州: 兰州大学硕士学位论文, 2021.WANG YJ. Study on skin microbiome of 24 China and Pakistani college students[D]. Lanzhou: Master’s Thesis of Lanzhou University, 2021 (in Chinese).
    [57] KIM HJ, KIM H, KIM JJ, MYEONG NR, KIM T, PARK T, KIM E, CHOI JY, LEE J, AN SS, SUL WJ. Fragile skin microbiomes in megacities are assembled by a predominantly niche-based process[J]. Science Advances, 2018, 4(3): e1701581.
    [58] CALLEWAERT C, RAVARD HELFFER K, LEBARON P. Skin microbiome and its interplay with the environment[J]. American Journal of Clinical Dermatology, 2020, 21(Suppl 1): 4-11.
    [59] 郝佳慧, 蔡伟杰, 李柯懋, 关弘弢, 杨朝杰, 高强, 刘丹, 聂苗苗, 祁得林, 张存芳. 高通量测序分析小头裸裂尻鱼皮肤和肠道的微生物多样性[J]. 微生物学报, 2023, 63(1): 233-250.HAO JH, CAI WJ, LI KM, GUAN HT, YANG ZJ, GAO Q, LIU D, NIE MM, QI DL, ZHANG CF. Skin and intestinal microbial diversity of Herzensteinia microcephalus determined by high-throughput sequencing[J]. Acta Microbiologica Sinica, 2023, 63(1): 233-250 (in Chinese).
    [60] 马明. 基于多组学分析高原林蛙响应高海拔胁迫的分子机制[D]. 兰州: 兰州大学博士学位论文, 2022.MA M. Analysis of the molecular mechanism of Rana kukunoris response to high altitude stress based on Mmulti-omics[D]. Lanzhou: Doctoral Dissertation of Lanzhou University, 2023 (in Chinese).
    [61] 徐亮亮. 海拔对两栖动物共生微生物(体表和肠道微生物)的影响[D]. 南京: 南京师范大学硕士学位论文, 2019.XU LL. Effects of altitude on symbiotic microorganisms (surface and intestinal microorganisms) of amphibians[D]. Nanjing: Master’s Thesis of Nanjing Normal University, 2019 (in Chinese).
    [62] EDSLEV SM, AGNER T, ANDERSEN PS. Skin microbiome in atopic dermatitis[J]. Acta Dermato-Venereologica, 2020, 100(12): adv00164.
    [63] BYRD AL, DEMING C, CASSIDY SKB, HARRISON OJ, NG WI, CONLAN S, COMPARATIVE SEQUENCING PROGRAM NISC, BELKAID Y, SEGRE JA, KONG HH. Staphylococcus aureus and Staphylococcus epidermidis strain diversity underlying pediatric atopic dermatitis[J]. Science Translational Medicine, 2017, 9(397): eaal4651.
    [64] FITZ-GIBBON S, TOMIDA S, CHIU BH, NGUYEN L, DU C, LIU M, ELASHOFF D, ERFE MC, LONCARIC A, KIM J, MODLIN RL, MILLER JF, SODERGREN E, CRAFT N, WEINSTOCK GM, LI HY. Propionibacterium acnes strain populations in the human skin microbiome associated with acne[J]. Journal of Investigative Dermatology, 2013, 133(9): 2152-2160.
    [65] JAHNS AC, LUNDSKOG B, GANCEVICIENE R, PALMER RH, GOLOVLEVA I, ZOUBOULIS CC, McDOWELL A, PATRICK S, ALEXEYEV OA. An increased incidence of Propionibacterium acnes biofilms in acne vulgaris: a case-control study[J]. The British Journal of Dermatology, 2012, 167(1): 50-58.
    [66] ALLHORN M, ARVE S, BRüGGEMANN H, LOOD R. A novel enzyme with antioxidant capacity produced by the ubiquitous skin colonizer Propionibacterium acnes[J]. Scientific Reports, 2016, 6: 36412.
    [67] O’NEILL AM, GALLO RL. Host-microbiome interactions and recent progress into understanding the biology of acne vulgaris[J]. Microbiome, 2018, 6(1): 177.
    [68] LEE HJ, KIM M. Skin barrier function and the microbiome[J]. International Journal of Molecular Sciences, 2022, 23(21): 13071.
    [69] NG CY, HUANG YH, CHU CF, WU TC, LIU SH. Risks for Staphylococcus aureus colonization in patients with psoriasis: a systematic review and meta-analysis[J]. The British Journal of Dermatology, 2017, 177(4): 967-977.
    [70] CHANG HW, YAN D, SINGH R, LIU J, LU XY, UCMAK D, LEE K, AFIFI L, FADROSH D, LEECH J, VASQUEZ KS, LOWE MM, ROSENBLUM MD, SCHARSCHMIDT TC, LYNCH SV, LIAO W. Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization[J]. Microbiome, 2018, 6(1): 154.
    [71] NAIK S, BOULADOUX N, WILHELM C, MOLLOY MJ, SALCEDO R, KASTENMULLER W, DEMING C, QUINONES M, KOO L, CONLAN S, SPENCER S, HALL JA, DZUTSEV A, KONG HD, CAMPBELL DJ, TRINCHIERI G, SEGRE JA, BELKAID Y. Compartmentalized control of skin immunity by resident commensals[J]. Science, 2012, 337(6098): 1115-1119.
    [72] 马晨, 张和平. 皮肤微生物与益生菌在皮肤疾病诊疗中的应用[J]. 食品科学, 2016, 37(9): 269-273.MA C, ZHANG HP. Skin microbiome and probiotic therapeutic approaches for skin diseases[J]. Food Science, 2016, 37(9): 269-273 (in Chinese).
    [73] WANG YZ, LI YX, XIE JM, ZHANG Y, WANG JL, SUN XL, ZHANG HP. Protective effects of probiotic Lactobacillus casei Zhang against endotoxin- and d-galactosamine-induced liver injury in rats via anti-oxidative and anti-inflammatory capacities[J]. International Immunopharmacology, 2013, 15(1): 30-37.
    [74] IEMOLI E, TRABATTONI D, PARISOTTO S, BORGONOVO L, TOSCANO M, RIZZARDINI G, CLERICI M, RICCI E, FUSI A, de VECCHI E, PICONI S, DRAGO L. Probiotics reduce gut microbial translocation and improve adult atopic dermatitis[J]. Journal of Clinical Gastroenterology, 2012, 46(Suppl): S33-S40.
    [75] LI H, WANG Y, YU Q, FENG T, ZHOU R, SHAO L, QU J, LI N, BO T, ZHOU H. Elevation is associated with human skin microbiomes[J]. Microorganisms, 2019, 7(12): 611.
    [76] YANG Y, QU L, MIJAKOVIC I, WEI Y. Advances in the human skin microbiota and its roles in cutaneous diseases[J]. Microbial Cell Factories, 2022, 21(1): 176.
    [77] BELKAID Y, SEGRE JA. Dialogue between skin microbiota and immunity[J]. Science, 2014, 346(6212): 954-959.
    [78] ZHANG X, DEEKE SA, NING ZB, STARR AE, BUTCHER J, LI J, MAYNE J, CHENG K, LIAO B, LI LY, SINGLETON R, MACK D, STINTZI A, FIGEYS D. Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease[J]. Nature Communications, 2018, 9(1): 2873.
    [79] NIELSEN TC, ROZEK T, HOPWOOD JJ, FULLER M. Determination of urinary oligosaccharides by high-performance liquid chromatography/electrospray ionization-tandem mass spectrometry: application to hunter syndrome[J]. Analytical Biochemistry, 2010, 402(2): 113-120.
    [80] GHAHREMANI-NASAB M, del BAKHSHAYESH AR, AKBARI-GHARALARI N, MEHDIPOUR A. Biomolecular and cellular effects in skin wound healing: the association between ascorbic acid and hypoxia-induced factor[J]. Journal of Biological Engineering, 2023, 17(1): 62.
    [81] WATSON M, HOLMAN DM, MAGUIRE-EISEN M. Ultraviolet radiation exposure and its impact on skin cancer risk[J]. Seminars in Oncology Nursing, 2016, 32(3): 241-254.
    [82] 王琰. 肠道菌与药物代谢[M]. 北京: 科学出版社, 2022: 355-365.WANG Y. Gut Microbiota and Drug Metabolism[M]. Beijing: Science Press, 2022: 355-365 (in Chinese).
    引证文献
    网友评论
    网友评论
    分享到微博
    发 布
引用本文

白雪,杨建鑫. 高原环境下皮肤微生物群对皮肤病影响的研究进展[J]. 微生物学报, 2025, 65(3): 968-980

复制
分享
文章指标
  • 点击次数:16
  • 下载次数: 25
  • HTML阅读次数: 16
  • 引用次数: 0
历史
  • 收稿日期:2024-11-06
  • 在线发布日期: 2025-03-10
文章二维码