2025年7月3日 周四
首页 > 过刊浏览>2025年第65卷第5期 >1958-1975. DOI:10.13343/j.cnki.wsxb.20240729
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细菌警报素(p)ppGpp代谢的关键调控者：RSH蛋白的功能多样性
作者:
作者单位:

1.西安交通大学口腔医院，陕西省颅颌面精准医学研究重点实验室, 陕西 西安;2.西安交通大学口腔医院，口腔种植科，陕西 西安;3.西安交通大学 生命科学与技术学院，教育部生物医学信息工程重点实验室，线粒体生物医学研究所， 陕西 西安

作者简介:

王淼：论文撰写、绘图和修改；项雨霏：论文撰写和修改；贺龙龙：文献收集和论文指导；周秦：论文指导和审阅；许丹：论文构思、指导和审阅。

基金项目:

国家自然科学基金(32270188)


Functional diversity of RSH proteins, key regulators of bacterial alarmone (p)ppGpp metabolism
Author:
  • WANG Miao 1,2

    WANG Miao

    Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China;Department of Implant Dentistry, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China
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  • XIANG Yufei 1,2

    XIANG Yufei

    Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China;Department of Implant Dentistry, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China
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  • HE Longlong 1,2

    HE Longlong

    Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China;Department of Implant Dentistry, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China
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  • ZHOU Qin 1,2

    ZHOU Qin

    Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China;Department of Implant Dentistry, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China
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  • XU Dan 1,3

    XU Dan

    Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China;Institute of Mitochondrial Biology and Medicine, Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, China
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Affiliation:

1.Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China;2.Department of Implant Dentistry, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China;3.Institute of Mitochondrial Biology and Medicine, Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, China

Fund Project:

This work was supported by the National Natural Science Foundation of China (32270188).

  • 摘要
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  • 访问统计
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  • 参考文献 [77]
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  • 相似文献 [1]
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    摘要:

    细菌的严紧反应(stringent response)是细菌在面临恶劣生存环境时，通过改变新陈代谢并降低生长速度，以增强存活和适应环境能力的一种适应性反应。此反应由鸟苷四磷酸(guanosine tetraphosphate, ppGpp)和鸟苷五磷酸(guanosine pentaphosphate, pppGpp) (合称(p)ppGpp)的快速积累所介导，在微生物应对环境变化中发挥关键作用。细菌内的(p)ppGpp水平由RelA/SpoT同源蛋白(RelA/SpoT homologues, RSH)调控，包括小警报素合成酶(small alarmone synthetases, SAS)、小警报素水解酶(small alarmone hydrolases, SAH)以及双功能蛋白Rel。此外，近期研究发现了一种新的细菌警报素腺苷四磷酸(adenosine tetraphosphate, ppApp)和腺苷五磷酸(adenosine pentaphosphate, pppApp) (合称(p)ppApp)，它能调控细菌的多种生物过程。鉴于不同细菌中涉及(p)ppGpp代谢的酶有所不同，本文对已知的RSH蛋白的结构及其生化特性进行系统的分类与综述，并总结其生物学功能，以促进未来在这一领域的深入研究与发展。

    Abstract:

    The bacterial stringent response refers to the adaptive reaction that bacteria exhibit when faced with adverse environmental conditions, altering their metabolism and reducing the growth rate to enhance survival and adaptability. The rapid accumulation of guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), collectively referred to as (p)ppGpp in this article, mediates the stringent response, playing a crucial role in microbial adaptation to environmental changes. The levels of (p)ppGpp within bacteria are regulated by RelA/SpoT homologue (RSH) proteins, which include small alarmone synthetases (SASs), small alarmone hydrolases (SAHs), and bifunctional proteins such as Rel. Furthermore, recent studies have identified a new bacterial alarmone, adenosine tetraphosphate (ppApp) and adenosine pentaphosphate (pppApp), collectively referred to as (p)ppApp, which is involved in the regulation of various biological processes in bacteria. The enzymes involved in (p)ppGpp metabolism vary among different bacterial species. This study systematically classifies and reviews the structural and biochemical characteristics of the known RSH proteins and summarizes their biochemical functions, aiming to promote further exploration and development in this field.

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王淼,项雨霏,贺龙龙,周秦,许丹. 细菌警报素(p)ppGpp代谢的关键调控者：RSH蛋白的功能多样性[J]. 微生物学报, 2025, 65(5): 1958-1975

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  • 收稿日期:2024-11-15
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