斑马鱼-海分枝杆菌模型研究对结核病致病机理的启示

Insight into tuberculosis pathogenic mechanism from the Zebra fish- mycobacterium marinum model?A review

摘要:

摘要：全世界约三分之一的人口感染过结核分枝杆菌，其导致的结核病仍然是全球公共卫生的严重威胁。结核菌是典型的胞内致病菌。结核菌的致病性与其成功逃避和利用宿主免疫应答等密切相关。控制结核病需要深入了解致病菌和宿主之间的相互作用。不同的动物模型是揭示致病菌－宿主相互作用的关键。海分枝杆菌-斑马鱼模型是最近才得以发展并获得了不少新见解的研究系统之一。本文总结了该模型揭示的海分枝杆菌毒力因子Erp、Esx-1、pmiA 、Mel1和Mel2、KasB等，以及该模型的优缺点。这些结果为大动物模型研究和深入了解结核分枝杆菌感染人体的致病机理提供了线索。

Abstract:

Abstract: Tuberculosis remains a major global health threat. Nearly one-third of the world population infected with Mycobacterium tuberculosis, the etiologic agent of tuberculosis. M. tuberculosis is a typical and most successful intracellular pathogen. The pathogen can evade and manipulate the host immune response. Insights into the interplays between the pathogen and the host was pivotal to develop more sophisticated diagnosis methods and control measures to tuberculosis. No single model can address the full spectrum of this extraordinarily successful pathogen. Multiple models are urgently needed to explore diverse facets of this human being scourge. Zebrafish- M.marinum model was increasingly recognized as an ideal system for preliminary studies. Some key findings emerging from this model were summarized in this paper, such as the interactions between host and M. marinum when the bacterium invades and the contribution of the virulence determinants of M.marinum such as Erp, Esx-1, pmiA, Mel and KasB. Discoveries from different models will be complementary and conducive to find clues to eradicate Mycobacterium tuberculosis.