芳香聚酮后修饰氧化酶

Post-modification oxygenases in the biosynthesis of aromatic polyketides?A review

摘要:

摘要：氧化酶在芳香聚酮生物合成后修饰中普遍存在并对终产物的结构产生关键影响。本文简要总结了芳香聚酮后修饰氧化酶中几类最常见的氧化酶的结构和功能，并以杰多霉素生物合成途径中的后修饰氧化酶为例，阐明这些氧化酶在后修饰反应中发生作用的方式。并对后修饰氧化酶在组合生物学中的应用做了展望。

Abstract:

Abstract：Oxygenases are common tailoring enzymes involved in the biosynthesis of aromatic polyketides, they are critical determinants of the final structure of aromatic polyketides. Here we review the structures and functions of several classes of oxygenases found in the biosynthetic gene clusters of aromatic polyketides. We used the oxygenases (JadFGH) in jadomycin biosynthesis as examples to elucidate the complex roles these oxygenases play and discussed the future prospects of using oxygenases in combinatorial biosynthesis.