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毒素-抗毒素系统抵抗噬菌体感染研究进展
作者:
作者单位:

1.福建师范大学 生命科学学院，福建 福州;2.福建师范大学，南方生物医学研究中心，福建 福州

作者简介:

朱青健：负责论文的撰写与修改；欧阳松应：对论文进行了审阅；王勖荣：负责绘图工作并汇总了相关文献。

基金项目:

国家自然科学基金(32300035)；福建省自然科学基金(2023J0123)


Toxin-antitoxin system resists phage infection: a review
Author:
Affiliation:

1.College of Life Science, Fujian Normal University, Fuzhou, Fujian, China;2.FJNU Biomedical Research Center of South China, Fujian Normal University, Fuzhou, Fujian, China

Fund Project:

This work was supported by the National Natural Science Foundation of China (32300035) and the Fujian Provincial Natural Science Foundation (2023J0123).

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    摘要:

    毒素-抗毒素(toxin-antitoxin, TA)系统广泛分布于细菌和古菌中。TA系统通常由一个能够抑制细菌生长的毒素和一个能够中和毒素毒性的抗毒素组成。目前，TA系统分为I-VIII型，其中II型TA系统的研究最为深入。然而，近年来也发现了一些非典型TA系统，如单顺反子TA系统和三组分TA系统等。自20世纪80年代发现首个TA系统(CcdB/CcdA)以来，TA系统被认为在微生物的多种生理过程中发挥重要功能。本文综述了近年来TA系统在抵抗噬菌体感染方面的功能，特别是TA系统如何特异性感知入侵噬菌体及其分子机制，旨在为探索未知TA系统的生物功能及调控机制提供参考。

    Abstract:

    The toxin-antitoxin (TA) system is ubiquitous in bacteria and archaea. A typical TA system generally consists of a toxin that inhibits bacterial growth and an antitoxin that neutralizes toxin toxicity. At present, TA systems are classified into types I-VIII, of which type II system is the most extensively studied. In addition, researchers have found that there are atypical TA systems such as monocistronic TA systems and three-component TA systems. After the discovery of the first TA system (CcdB/CcdA) in the 1980s, TA systems have been shown to play a key role in the physiological processes of microorganisms. In this paper, we review the research results about the roles of TA systems in resisting bacteriophage infections in recent years and summarize the neutralization mechanisms. In particular, we brief how TA systems specifically sense the invading bacteriophages and the underlying molecular mechanisms, aiming to provide reference for the research on the roles and regulation mechanisms of unknown TA systems in the future.

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朱青健,欧阳松应,王勖荣. 毒素-抗毒素系统抵抗噬菌体感染研究进展[J]. 微生物学报, 2025, 65(3): 1007-1016

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  • 收稿日期:2024-10-14
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