高通量测序技术及其在微生物学研究中的应用

Next-generation sequencing technologies and the application in microbiology - A review

摘要:

摘要：20世纪70年代发明的核酸测序技术为基因组学及其相关学科的发展做出了巨大贡献，本世纪初发展的以Illumina公司的Solexa，ABI公司的SOLiD，和Roche公司的454技术为代表的高通量测序技术又为基因组学的发展注入了新活力。本文在阐述这些技术的基础上，着重讨论了新一代测序技术在微生物领域中的应用。

关键词:关键词：新一代测序技术;高通量;微生物学;应用;基因组学

Abstract:

Abstract: Since its invention in 1970s, nucleic acid sequencing technology has contributed tremendously to the genomics advances. The next-generation sequencing technologies, represented by Solexa from Illumina, SOLiD from Applied Biosystems and 454 from Roche, re-energized the application of genomics. In this review, we first introduced the next-generation sequencing technologies, then, described their potential applications in the field of microbiology.

Key words:Keywords: next-generation sequencing technology; high-throughput; microbiology; application; genomics