丝状真菌新型全局性调控因子LaeA

Research advances in global regulator LaeA of filamentous fungi—A review

摘要:

摘要: 全局调控在丝状真菌次级代谢调控及其生长发育过程中有着重要的作用。LaeA 是2004 年首次在构巢曲霉中被发现的第一个丝状真菌全局性调控因子，继而在烟曲霉、黄曲霉、产黄青霉、橘青霉中相继被报道。LaeA 能够全局性调控抗生素和真菌毒素等次级代谢产物的合成，影响真菌形态分化，另外还通过影响沉默基因的表达从而调控未知代谢产物的产生，因而能为真菌中天然产物的开发提供新的重要途径。本文就其在丝状真菌中的发现、功能、作用机制及其应用等方面进行综述。

Abstract:

Abstract: Global regulators play an important role in secondary metabolite biosynthesis and morphological development in filamentous fungi． LaeA，a key global regulator in filamentous fungi was found in 2004，regulating the expression of a variety of fungal natural product gene clusters． Besides regulation of beneficial metabolism，fungal toxin biosynthesis and morphological developmental processes，laeA also contributed to activating the expression of cryptic gene clusters and resulted in generating novel secondary metabolites． Although the mechanism of LaeA on gene activation is still unclear，it has set the stage for understanding the fungal regulatory network and discovering new natural products． This review highlight its discovery，function and regulatory mechanism in filamentous fungi．