产Ⅱ类细菌素乳酸菌群体感应及其应用

Quorum sensing in class II bacteriocin-producing lactic acid bacteria and its application -A review

摘要:

摘要: 群体感应(quorum sensing，QS)是微生物通过感知与细胞密度相关的信号分子的浓度来调控基因表达的一种行为。许多产Ⅱ类细菌素乳酸菌通过自诱导肽介导的QS 系统调控其细菌素的合成。本文综述了乳酸菌Ⅱ类细菌素合成的QS 调控现象、调控机制、QS系统组分以及QS 的应用。产Ⅱ类细菌素乳酸菌QS的研究，必将为揭示发酵调控机理、调控发酵过程提供新的研究平台，为食品级基因表达系统的开发提供新的选择。

Abstract:

Abstract: Quorum sensing (QS) refers to the behavior of microorganisms to control gene expression through detection the concentration of certain signal molecules，which is correlated with cell density． In many class Ⅱ bacteriocin-producing lactic acid bacteria (LAB)，bacteriocin production is regulated by peptide pheromones via a QS mechanism． We reviewed，QS regulated class Ⅱ bacteriocin production in LAB and its regulation mechanism，components of the QS system，as well as the application of QS mechanism． The study of QS mechanism of class Ⅱ bacteriocin-producing LAB may provide a new platform for revealing the mechanism of fermentation control and regulating fermentation process． It also offers an alternative to the exploitation of food grade gene expression system．