2025年3月15日 周六
首页 > 过刊浏览>2025年第65卷第3期 >1017-1032. DOI:10.13343/j.cnki.wsxb.20240605
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巨型噬菌体的研究进展
作者:
作者单位:

1.陆军军医大学 基础医学院，微生物学教研室，重庆市微生物工程重点实验室，重庆;2.陆军军医大学 第一附属医院(重庆西南医院) 心血管内科，重庆

作者简介:

何博：文章撰写，绘制图5、图6，引用图1、图7；姜昕宇：文章审阅；廖江林：生物信息学统计分析，绘制图3、图4；卢曙光：文章审核与修改，整理相关数据并绘制图2；乐率：综述选题及确定文章主旨和结构，文章修改。

基金项目:

国家重点研发计划(2021YFA0911200)


Research progress in jumbo phages
Author:
Affiliation:

1.Key Laboratory of Microbial Engineering under the Educational Committee in Chongqing, Department of Microbiology, College of Basic Medical Sciences, Army Medical University, Chongqing, China;2.Department of Cardiovascular Medicine, the Southwest Hospital of Army Medical University, Chongqing, China

Fund Project:

This work was supported by the National Key Research and Development Program of China (2021YFA0911200).

  • 摘要
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  • 参考文献 [98]
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    摘要:

    在后抗生素时代，噬菌体疗法是对抗耐药菌的重要候选武器。噬菌体具有丰富的多样性，其中的巨型噬菌体是一类基因组大于200 kb的噬菌体。由于其基因组容量大，功能基因类型丰富且排布分散。巨型噬菌体在生物学机制上具有许多特性，如拥有超大的噬菌体颗粒、独特的复制周期和结构(如核状区室、内体和长波浪卷曲尾丝)等。本文旨在对巨型噬菌体及其研究进展进行综述，重点剖析其生物学特点、基因组与进化、特殊的复制机制与结构，并探讨其在抗耐药菌感染、环境治理、水产养殖和生物防治等领域的应用潜力，为巨型噬菌体的相关研究和应用提供参考与启示。

    Abstract:

    In the post-antibiotic era, phage therapy becomes a candidate for treating drug-resistant bacteria. Phages are diverse, and jumbo phages are a class of phages with genomes longer than 200 kb. Their large genomes carry abundant functional genes with scattered distribution. Jumbo phages have a variety of unique biological characteristics, such as oversized phage particles, unique replication cycles, and unique structures such as the nucleus-like compartment, the “inner body”, and the long-wavy curly tail fiber. This paper reviews the research progress in jumbo phages, focusing on their biological characteristics, genomes, evolution, and special replication mechanisms and structures. Furthermore, this review explores the application potential of jumbo phages in the treatment of drug-resistant bacterial infection, environmental management, aquaculture, and biocontrol, aiming to provide reference and implications for the research and application of jumbo phages.

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何博,姜昕宇,廖江林,卢曙光,乐率. 巨型噬菌体的研究进展[J]. 微生物学报, 2025, 65(3): 1017-1032

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