动物源产肠毒素大肠杆菌(ETEC)黏附素研究进展

Fimbriae of animal-originated Enterotoxigenic Escherichia coli—A review

摘要:

摘要:动物源产肠毒素大肠杆菌(enterotoxigenic Escherichia coli，ETEC)是引起动物(尤其是幼龄动物)腹泻的主要病原菌。已知黏附素和肠毒素是ETEC 中两种重要的毒力因子，在致病性中两者缺一不可。其中黏附素结合到宿主易感肠上皮细胞是ETEC 感染的第一步，也是最重要的关键步骤。动物源ETEC的菌毛黏附素主要包括K88、K99、987P、F18、F17 和F41 等。人们从20 世纪60 年代就开始了ETEC 菌毛黏附素的相关研究，包括菌毛的基因、结构组成、生物合成、菌毛表达的调控机制以及黏附素和宿主受体相互作用等，这些研究基础有助于我们深入了解ETEC 病原菌的感染机理;并且在疾病诊断和新疫苗的开发中具有重大意义。

Abstract:

Abstract:Animal-originated enterotoxigenic Escherichia coli (ETEC) are major pathogens resulting in newborn and young animal diarrhea． Adhesins and enterotoxins，both are essential for the pathogenicity of ETEC，are two major virulent factors of ETEC． Adhesion of animal-originated ETEC fimbrial adhesins (mainly including K88，K99，987P，F18，F17 and F41) to intestinal epithelial cells is the initial and most important step involved in the ETEC infection． From the 1960s，studies on ETEC fimbrial genes，structure，biosynthesis，regulation of expression，interaction between fimbriae and host receptors have helped to better understand the biology and role of these organelles in pathogenesis． These studies also provide insight into new diagnostic tools and development of vaccines and inhibitors of ETEC colonization．