阪崎肠杆菌分类与致病机制

Taxonomy and pathogenic mechanism of Cronobacter（Enterobacter sakazakii）－A review

摘要:

摘要：作为一种重要的食源性致病菌，阪崎肠杆菌因能引起新生婴幼儿脑膜炎、坏死性小肠结肠炎而受到了政府和社会的高度重视。2008年，阪崎肠杆菌被提议重新另立为隶属于肠杆菌科的一个包含有5个新种的新属——Cronobacter gen. Nov.。新属的五个种之间毒力作用存在差异，外膜蛋白A在黏附和抗吞噬过程中发挥了重要作用，同时本属菌株的侵入力在宿主细胞间的紧密联系被破坏时显著提高，但是一些肠道益生菌能抑制该菌侵入。目前阪崎肠杆菌的致病研究还比较分散，没有形成系统性，详细的致病机制期待进一步阐明。

Abstract:

Abstract: Enterobacter sakazakii is an important food-borne pathogen that causes life-threatening meningitis and necrotizing colitis in neonates and children. In 2008, Enterobacter sakazakii has been reclassified as five species in a new genus, Cronobacter gen. nov. within the Enterobacteriaceae. There is the variation in virulence between species in the new genus. OmpA of Cronobacter gen. nov. plays a critical role in attachment to their host cell and persistence within macrophages . Disruption of the tight junction significantly enhances the efficiency of invasion. Specific probiotic strains and their combinations counteract adhesion of Cronobacter gen. nov to intestinal mucus. At present, very limited information is available regarding the pathogenesis of Cronobacter gen. nov. Further detailed mechanism studies on the pathogenicity are warranted.