神经氨酸酶、碱性聚合酶2及非结构蛋白1影响A型流感病毒致病力的分子机制研究进展

Research progress in molecular determinants of neuraminidase, polymerase basic protein 2 and nonstructural protein 1, related to virulence of influenza A virus - A review

摘要:

摘要：随着研究的不断深入，血凝素（HA）之外的其他蛋白在影响A型流感病毒的致病力甚至宿主特异性方面具有的重要作用逐渐被证实。本文对神经氨酸酶（NA）、碱性聚合酶2（PB2）及非结构蛋白1（NS1）的相关进展作了综述，以期进一步阐明流感病毒的致病分子基础，并藉此探讨可能的宿主范围限定因素。

Abstract:

Abstract: It is gradually recognized that host specificity and pathogenicity of influenza A virus could also be affected by proteins other than hemagglutinin (HA) due to its polygenic nature. In this review, detailed description was focused mainly on neuraminidase (NA), polymerase basic protein 2 (PB2) and nonstructural protein 1 (NS1), especially their molecular determinants associated with virulence and host range restriction of influenza A virus.