犬细小病毒:从起源到进化

Origin and evolution of Canine parvovirus—A review

摘要:

摘要:犬细小病毒(Canine parvovirus，CPV-2) 首次分离于1978 年，被认为是由遗传关系相近的猫泛白细胞减少症病毒( FPLV) 或其他肉食兽细小病毒( FPLV-like virus) 跨宿主感染犬产生的新病原。其感染能引起新生犬急性心肌炎或幼犬出血性肠炎，造成较高的发病率和死亡率。该病原爆发后短短一年时间内即广泛流行到世界各地。随着CPV-2 对宿主的适应和变异，新抗原变异型( CPV-2a、CPV-2b 和CPV-2c) 不断产生并在世界各地逐步替代了CPV-2 的流行。伴随C

Abstract:

Abstract:Canine parvovirus(CPV-2) ，first recognized in 1978 as a new pathogen of dogs，was probably derived from a very closely related virus in cats，feline panleukopaenia virus ( FPLV) or a closely related carnivore parvovirus ( FPLVlike virus) ． CPV-2 is responsible for either myocarditis or fatal gastroenteritis in pups with high morbidity and mortality．Shortly after its emergence，CPV-2 has become endemic in the global dog population． The original CPV-2 continued to evolve，and was subsequently replaced by three different but closely related antigenic variants，designated CPV-2a，CPV- 2b and CPV-2c，which now coexist in dog populations worldwide． The genetic and antigenic variation in CPV-2 also correlated with changes in the host range and tissue tropisms of the virus． Here，we reviewed variation and evolution of CPV-2 in past 30 years and discussed CPV-2 as an important model to study virus evolution．