芽胞杆菌的表层蛋白研究及应用前景

Progress and perspectives of surface layer proteins from Bacillus species—A review

摘要:

摘要:细菌表层蛋白(surface layer protein，S-层蛋白) 是由同种蛋白质或糖蛋白亚基装配而成，广泛分布于各种古生菌和真细菌表面，形成的多孔网状结构。成熟的S-层蛋白一般具有两个功能域———特异性锚定区域和自组装区域。近年来基于芽胞杆菌属几种细菌的S-层蛋白的研究已经成为热点，其在生物传感器、疫苗研制、表面展示、纳米材料、生物治理等方面具有广泛的应用前景。本文就芽胞杆菌S-层蛋白的结构，生化遗传，功能，病源相关性及其在工业和生物医学上的应用进行综述。

Abstract:

Abstract:S-layer proteins are crystalline arrays composed of numerous identical protein or glycoprotein subunits． They comprise the outermost cell envelope component in most archaea and many bacteria． The remarkable properties of S-layer proteins are their capability to self-assemble and specific binding，which give S-layer proteins a wide application potential in nanotechnology and biomimetics． Recently most study in this field was concerned on the S-layer proteins of Bacillus species． This review provided a brief survey of the current state of the study about the genetics，function，properties，pathogenic correlation and application of the S-layer proteins of Bacillus species． The aim of this review was to gain more knowledge about the function of S-layers and lead to the development of new types of surface display system and recombinant vaccines，diagnostic agents and biocompatible surfaces．