西北农林科技大学动物医学院，兽医免疫学研究所，杨凌712100

Detection and description of avian hepatitis E virus isolated in China—A review

摘要:

摘要:禽戊型肝炎病毒(Hepatitis E virus，HEV) 与人、猪HEV 同属于肝炎病毒属，它们在遗传性和抗原性上有一定的相关性。自禽HEV 被分离鉴定以来，许多国家从血清学或分子流行病学方面证实了该病毒的存在和流行。目前，GenBank 上共有5 个禽HEV 的全基因组或接近全基因组的序列，分为3 个基因型，并且其全基因组包含3 个ORFs，其中ORF2 基因编码病毒的衣壳蛋白，包含病毒主要的抗原表位，是血清学检测和疫苗设计的主要靶蛋白。禽HEV 由于其对家禽养殖业的危害以及人畜共患的可能性，正被引起越来越多的关注。本文结合国内禽HEV 的分离鉴定从禽HEV 病原学、致病性以及衣壳蛋白抗原性等方面进行了总结概述。

Abstract:

Abstract:Avian hepatitis E virus (HEV)，a member of Hepeviridae family，is genetically and antigenically related with human and swine HEV in the family． Since its discovery，avian HEV infection has been investigated in many countries from serology and molecular epidemiology studies． At present，five complete or near complete genomes of avian HEV isolates were reported in GenBank and were divided into three genotypes．The complete genome of avian HEV contains 3 ORFs of which ORF2 gene encodes capsid protein containing the primary epitopes of viral particles and is target gene for serodiagnostic antigen and vaccine candidate． Because avian HEV infection has significant impact on the poultry industry and potential zoonotic transmission，the researches on avian HEV have been given much attention． We here give a broad review of the research update on the aetiology，pathogenesis and the antigenicity of capsid protein of avian HEV based on identification of Chinese avian HEV isolate．