放线菌中腺苷三磷酸结合盒转运蛋白的研究进展

Research advances in actinomycete ATP-binding cassettetransporters—A review

摘要:

摘要:放线菌由于能产生多种结构新颖、活性独特的次级代谢产物，在医药工业、农业和环境保护上具有重要作用。全基因组测序的数据显示，放线菌中含有数目众多的腺苷三磷酸结合盒(ATP-binding cassette，ABC)转运蛋白基因，在营养摄入、次级代谢产物转运、外源毒素解毒等一系列过程中发挥着重要的作用。本文概述了ABC 转运蛋白的结构和作用机制，并结合本实验室的研究工作，对近年来放线菌中ABC 转运蛋白的研究进展进行了比较全面的综述，着重介绍了负责次级代谢产物跨膜转运的ABC 外排蛋白，并展望了放线菌ABC 转运蛋白的研究热点和应用前景。

Abstract:

Abstract:Actinomycetes can produce numerous secondary metabolites with novel structures and unique bioactivities，which are significant for pharmaceutical industry，agriculture and environmental protection． Whole-genome sequencing data demonstrate that actinomycetes contain plenty genes coding for transporters with ATP-binding cassette (ABC)，which play important roles in nutrient uptake，secondary metabolite export，xenogenous toxin detoxification，and so on． In this review，the structures and mechanisms of the ABC transporters were described． We also comprehensively discussed research advances including ours on actinomycete ABC transporters，with emphasis on ABC exporters responsible for the secretion of secondary metabolites． Finally，research hotspots and application prospect of actinomycete ABC transporters were also addressed．