自噬对胞内感染病原菌的清除及促进增殖作用

Influence of autophagy on elimination and proliferation of intracellular bacteria—A review

摘要:

摘要:自噬作为一种新的程序性细胞死亡，其在病原体感染中的地位日益受到广泛关注。自噬在病原体感染中具有“双刃剑”样作用，一方面，机体可利用自噬清除感染入侵的病原体;另一方面，自噬可被某些病原体利用、修饰或干扰，以促进自身在宿主细胞内的存活与增殖。本文拟就近年来自噬与人类疾病关系密切的胞内病原菌感染中的作用及地位进行综述，同时结合本室研究进行一定深入探讨，为探索通过调控及合理利用自噬途径预防和控制感染性疾病的发生发展提供理论依据。

Abstract:

Abstract:Autophagy in intracellular bacterial infection is important． Host cells can use autophagy to eliminate invading pathogens． Meanwhile，autophagy can be exploited，modified or interfered by some pathogens to benefit their survival or proliferation． We reviewed the effect of autophagy on intracellular bacterial infection and discussed our study on the relationship between autophagy and Salmonella infection，which can help provide the theoretical basis for controlling pathogenic infection through regulating and exploiting autophagic pathway．