人和动物胃肠道微生物丁酸合成途径相关酶基因的研究进展

Genes and gene clusters involved in microbial butyrateproducing pathway of human and animal gastrointestinal tract

摘要:

摘要:人和动物胃肠道中都栖息了大量的产丁酸微生物。研究表明，参与丁酸合成中心途径的酶基因成簇存在，其相关基因的排列形式多样并具有属种特异性。参与丁酸合成最后一步的(丁酰辅酶A/乙酸)辅酶A(CoA)转移酶在胃肠道产丁酸微生物中广泛存在，并在丁酸合成中发挥重要作用。本文结合我们的研究工作，综述了国内外丁酸合成相关酶基因和基因簇的最新研究进展。

Abstract:

Abstract:Human colon and animal digestive tract harbor large amount of butyrate-producing bacteria．The biosynthetic pathway of butyrate formation includes the central pathway from acetyl-CoA to butyryl-CoA and the last step converting butyryl-CoA to butyrate． The genes involved in the central pathway are clustered in genome but with different gene arrangements in different bacteria groups． The gene arrangements are coherent with their phylogenetic placements based on their 16S rRNA gene sequences． Recent researches have suggested that butyryl-CoA: acetate CoA-transferase play an important role in the last step of butyrate formation from butyryl-CoA and the genes are also widely found in bacterial strains producing butyrate． In this paper，combined with our own findings，we summarized advances in studying genes and gene clusters involved in butyrate formation.