光滑球拟酵母生理功能解析与调控

Physiological function in Torulopsis glabrata—A review

摘要:

摘要:多重维生素营养缺陷型光滑球拟酵母(Torulopsis glabrata)，是工业发酵生产丙酮酸最具竞争力的菌株。由于其独特的基因组特征和优越的生产表型，通过营养、环境条件和辅因子水平能有效地调控T.glabrata 的生理功能，进而将代谢流最大化、快速化的导向目标产物。本文总结了T.glabrata 在基因组测序、生理功能解析与调控等方面所取得的研究进展，并评估了利用T.glabrata 生产精细化学品的潜力。

Abstract:

Abstract:A multi-vitamin auxotrophic yeast of Torulopsis glabrata was the most competitive strain for industrial production of pyruvate． Given its genomic characterizations and physiological functions，it was an efficient way to redirect carbon flux to the target metabolites through manipulating nutritional and environmental conditions，intracellular cofactor form and level． In this review，we summarized the progress on the elucidation and manipulation of physiological function of T.glabrata. Furthermore，we also evaluated the potential of T．glabrata as cell factory for production of fine chemicals．