microRNA 对宿主和肠道微生物互作的调控

microRNA regulation on host-microbiota interaction—A review

摘要:

摘要:肠道内环境是宿主和肠道微生物菌群互作的结果，肠道菌群一方面通过抗原物质调节肠道组织的免疫稳定，另一方面，肠道菌群参与糖、脂、蛋白质代谢，产生的代谢产物能够调控细菌营养代谢、群体结构和肠道组织的营养吸收等。microRNA是宿主细胞内调控基因表达的重要因子，肠道微生物菌群不仅调控宿主mRNA的转录，同时也影响某些基因的转录后修饰。研究表明，肠道菌群通过与宿主肠道组织互作，调节肠上皮组织内某些参与炎症应答和屏障功能的microRNA 的表达。本文介绍了肠道微生物与宿主互作的基本内容，对microRNA在肠道微生物与宿主互作和肠道健康中的调节进行综述。

Abstract:

Abstract:The intestinal environment is dependent on the host-microbiota interaction．Antigens of gut microbiota could affect the intestinal immunological homeostasis．Gut microbiota also participate in the metabolism of carbohydrate，lipid and protein． In return，the metabolites from these metabolic processes could regulate the bacterial metabolism，community composition and intestinal nutrient assimilation． MicroRNA serves as an important intracellular factor that regulates host gene expression．Gut microbiota could affect the host mRNA transcription and the post-transcription modification of certain genes by microRNA．Recent researches have revealed that gut microbiota could change the expression of microRNAs involved in gut inflammation and mucosal barrier via host-microbiota interaction．In this paper，we summarized recent advances in host-microbiota interaction and highlighted the research about microRNA regulation on gut homeostasis and host-microbiota interaction．