Abstract:Growing attention has been focused on probiotic lactic acid bacteria because of their important health-promoting effects. Nowadays,probiotic-based products have become fashionable nutraceuticals of choice.Before a newly developed probiotic-based product is to be introduced into the industry,it is important to ensure not only the desirable properties of the probiotic strain but also a good genetic stability. This article firstly introduces the research methods for investigating genetic stability,followed by summarizing the latest research progress in China and overseas.