洋葱伯克氏菌致病因子的研究进展

Advances in virulence determinants in Burkholderia cepacia complex—A review

摘要:

摘要: 洋葱伯克氏菌群(Burkholderia cepacia complex，Bcc)大部分成员是重要的人类条件致病菌。虽然其分类学和分子鉴定研究已取得较大进展，但致病分子机理尚不明确，新药物开发进展十分缓慢。Bcc对许多常用临床抗菌药物都有耐药性，因此揭示其致病因子对新型抗菌药物或治疗方法开发具有重要意义。本文对Bcc主要致病因子、致病机理研究中存在的问题和采用的遗传工具方面的进展做了综述，重点介绍了耐药性、蛋白分泌系统、群体感应系统等6类重要致病因子。

Abstract:

Abstract: Most members of the Burkholderia cepacia complex (Bcc) are important human opportunistic pathogens．Although progress has been achieved on the taxonomy and molecular identification of these bacteria，the molecular mechanisms of Bcc pathogenicity remain unclear and little development is made for new therapeutic agents．As Bcc is resistant to many common clinically-relevant antibiotics，revealing its virulence determinants is therefore very important to develop novel antibiotics or alternative anti-infective therapies．In this review，we summarize current advances in principal virulence determinants，limitations and genetic tools for studies of pathogenesis of Bcc．We primarily focus on key pathogenicity factors，including innate resistance to antibiotics，protein secretion system，and quorum-sensing systems．