结核分枝杆菌ABC转运蛋白与物质的跨膜转运

ATP-binding cassette transporters and transmembrane transport in Mycobacterium tuberculosis-A review

摘要:

摘要:结核分枝杆菌作为一种胞内寄生菌，主要存在于巨噬细胞吞噬体内，并且通过与宿主细胞竞争摄取营养物质、主动排出有毒物质来维持生存。因此，参与上述过程的ABC 转运蛋白在结核分枝杆菌的致病中发挥着举足轻重的作用。已有报道结核分枝杆菌基因组编码了38个ABC转运蛋白。这类蛋白质有着广泛的底物结合谱，参与了无机离子、糖类、氨基酸、寡肽、药物等多种物质的跨膜转运。本文将对结核分枝杆菌编码的ABC转运蛋白超家族中的不同成员及其底物特异性、转运机制以及与毒力的关系的研究进展进行综述。

关键词:关键词:结核分枝杆菌，ABC 转运蛋白，底物特异性，转运机制，致病力

Abstract:

Abstract:Mycobacterium tuberculosis，an intracellular bacterium，mainly lives in the phagosome of the macrophage．It utilizes competitive uptake of nutrients as well as active efflux of noxious compounds to maintain its survival．Thus，the ATP-binding cassette transporters involved in either process mentioned above are essential for its pathogenicity．There are 38 ATP-binding cassette transporters identified in the genome of M．tuberculosis．This sort of proteins facilitate the transport of various substrates ranging from ions，sugars，amino acids，oligopeptides and drugs．In this review，we summarized the substrate specificity and transport mechanism of these transporters and their relationship with virulence in M．tuberculosis．

Key words:Keywords: Mycobacterium tuberculosis，ATP-binding cassette transporters，substrate specificity，transport mechanism，pathogenicity