调控乳酸菌酸胁迫抗性研究进展

Regulating acid stress resistance of lactic acid bacteria－A review

摘要:

摘要:作为工业化的细胞工厂，乳酸菌广泛应用于食品、农业和医药等行业。酸胁迫是乳酸菌在发酵生产以及作为益生菌在人体胃肠道系统中广泛存在的一种环境胁迫，严重影响乳酸菌的生理功能。近年来，随着系统生物学和代谢工程等技术的发展，为进一步揭示乳酸菌酸胁迫抗性机制并提高其耐酸性能带来了可能。本文综述了乳酸菌酸胁迫研究进展，介绍了乳酸菌应对酸胁迫的生理机制，并提出了提升乳酸菌酸胁迫抗性的策略。

Abstract:

Abstract:As cell factories，lactic acid bacteria are widely used in food，agriculture，pharmaceutical and other industries．Acid stress is one the important survival challenges encountered by lactic acid bacteria both in fermentation process and in the gastrointestinal tract．Recently，the development of systems biology and metabolic engineering brings unprecedented opportunity for further elucidating the acid tolerance mechanisms and improving the acid stress resistance of lactic acid bacteria． This review addresses physiological mechanisms of lactic acid bacteria during acid stress．Moreover，strategies to improve the acid stress resistance of lactic acid were proposed．