母体与外界环境影响新生儿肠道微生物区系建立的研究进展

Influences of maternal and external environment on the early establishment of gastrointestinal microflora of neonatal baby－A review

摘要:

摘要:肠道微生物在宿主营养吸收、器官发育、抵抗病原菌入侵以及调节免疫应答等方面是不可或缺的。新生儿早期建立的微生物区系与成年人的微生物区系有很大的不同，容易受到母体和外界环境因素的影响，经历由少到多，从简单到复杂和从不稳定到稳定的过程。本文对影响新生儿早期肠道微生物区系建立的因素进行综述，系统阐述分娩时间、分娩方式、喂养方式以及抗生素这几种重要因素对微生物区系变化所产生的作用。

Abstract:

Abstract:The human intestinal microbiota is essential in nutrients utilization，organ development，host metabolism，pathogen resistance，and regulation of immune responses．The establishment of early gut microflora in newborn infants experiences periods from less to more，simple to complex and unstable to stable and can be influenced by various factors．This article summarizes the effects of delivery mode，delivery period，rearing methods as well as antibiotics on the development of intestinal bacterial community．