猪链球菌的烈性噬菌体和前噬菌体

Lytic phages and prophages of Streptococcus suis-A review

摘要:

摘要:猪链球菌(Streptococcus suis，S. suis)是一种重要的人畜共患病病原，携带有前噬菌体。本文对猪链球菌的烈性噬菌体和前噬菌体的研究现状做了综述，主要包括猪链球菌烈性噬菌体的形态及功能;烈性噬菌体裂解酶的结构及功能;烈性噬菌体末端酶大亚基的活性;前噬菌体的比较基因组学、前噬菌体的裂解酶以及烈性噬菌体和溶原性噬菌体之间的相互转化，并对猪链球菌噬菌体与宿主的相互关系作了展望。

Abstract:

Abstract:Streptococcus suis (S. suis) is an important zoonosis and pathogen that can carry prophages．In this review，we focus on the recent advances in our understanding of lytic phage and lysogenic phage of S. suis，including the morphology of S. suis lytic phage，the functions of lysin and terminase large subunit encoded by S. suis lytic phage，comparative genomics of S. suis prophages，lysogenic conversion between S． suis lytic phage and prophage．Furthermore，prospective evolution of interactions between phage and host was discussed．