杆状病毒经口感染及经口感染因子研究进展

Advances in baculovirus per os infection and per os infectivity factor-A review

摘要:

摘要:杆状病毒(Baculovirus)是一类专一性感染节肢动物的病原微生物，其宿主主要为鳞翅目、双翅目及膜翅目昆虫。在自然界中，杆状病毒通过经口感染的方式在其宿主中建立感染，其中杆状病毒经口感染因子发挥着重要的作用。本文回顾了杆状病毒的基本特性，阐述杆状病毒建立经口感染在进化上的必要性以及在此过程中的主要事件，包括杆状病毒经口感染方式的进化、病毒粒子与昆虫中肠微绒毛细胞的结合和融合等，并着重介绍杆状病毒经口感染因子的鉴定和功能研究。这些研究对人类了解和利用杆状病毒进行生物防治和外源基因表达具有重要的指导意义。

关键词:关键词:杆状病毒，经口感染，经口感染因子

Abstract:

Abstract:Baculoviruses are a family of arthropod-specific viruses that mainly affect insects of the orders Lepidoptera，Hymenoptera，and Diptera．In nature，baculoviruses establish infection in their hosts orally and a battery of proteins designated as per os infectivity factors play pivotal roles in baculovirus per os infection．This review summarizes the basic characteristics of baculovirus and discusses the main events that baculovirus establishes per os infection，including the evolutionary advantages for baculovirus to initiate infection through the oral route，the binding and fusion of baculovirus virions with insect midgut microvilli and the functional roles of baculovirus per os infectivity factors．These achievements and advances should promise to shed light on the understanding and utilization of baculovirus for bio-control and exogenous gene expression in the future.

Key words:Keywords: Baculovirus，per os infection，per os infectivity factor