杆状病毒编码的内核膜分选模序研究进展

Research progress on baculovirus encoded inner nuclear membrane sorting motif -A review

摘要:

摘要:杆状病毒(Baculovirus)是一类在自然界中专一性感染节肢动物的病原微生物，其宿主主要为鳞翅目、双翅目及膜翅目昆虫。杆状病毒感染其宿主细胞时产生多种整合膜蛋白，通过细胞连续膜系统，从内质网、外核膜到内核膜，并最终定位到病毒粒子囊膜上。杆状病毒编码的内核膜分选模序作为一种蛋白分选信号序列，在此过程中发挥关键作用。本文对杆状病毒编码的内核膜分选模序研究进展进行综述，包括其作为一种新型蛋白定位信号的分子作用机理和分选作用模型，以及与杆状病毒经口感染之间的关系。这些研究不仅在分子水平上丰富和补充了人们对蛋白分选机制的认识，而且对于杆状病毒分子生物学研究和应用具有重要的推动意义。

Abstract:

Abstract:Baculoviruses are a family of arthropod-specific viruses that mainly affect insects of the orders Lepidoptera，Hymenoptera，and Diptera．During baculovirus infection，an amplified pulse of integral membrane proteins was synthesized．The proteins use continuous membranes of the endoplasmic reticulum，outer nuclear membrane and inner nuclear membrane during their transport to the viral envelope of the occlusion-derived virus．The baculovirus encoded inner nuclear membrane sorting motif (INM-SM) functions as a sorting signal and plays pivotal roles in these processes．This review focuses on recent advances in understanding of baculovirus encoded INM-SM，including the molecular mechanisms underlining protein sorting and trafficking by INM-SM，the possible model of INM-SM involvement in integral membrane proteins trafficking and the role of INM-SM in baculovirus per os infection． These achievements and advances should help to expand the molecular understanding of protein trafficking，baculovirus molecular biology and its application in the future．