微生物未甲基化CpG DNA对动物肠道的免疫调节作用

Advances in immunomodulation of microbial unmethylated CpG DNA on animal intestinal tract－A review

摘要:

摘要:微生物未甲基化CpG DNA为富含未甲基化胞嘧啶-鸟嘌呤二核苷酸的DNA片段，能够被动物肠道细胞Toll样受体家族中的TLＲ9 受体(Toll-like receptor 9，TLR9)特异性识别。未甲基化CpG DNA作为一种动物肠道免疫刺激因子，不仅能够直接调节肠道固有免疫应答，同时还能间接介导肠道适应性免疫应答。未甲基化CpG DNA具有调节机体免疫应答作用的应用前景，成为免疫佐剂开发的研究热点。本文主要综述微生物未甲基化CpG DNA基本概念、受体TLR9的特征、调节动物肠道免疫作用及其信号机制，同时阐述了未甲基化CpG DNA作为免疫佐剂在实际中的应用，最后对微生物未甲基化CpG DNA研究与开发利用前景进行了展望。

Abstract:

Abstract:Unmethylated cytosine-guanine (CpG) dinucleotides motifs in bacterial DNA can be recognized by specific Tolllike receptor 9 (TLR9) in intestinal cells．As one of the intestinal immunostimulatory factors，unmethylated CpG DNA can modulate intestinal innate immune responses directly and adaptive immune responses indirectly．There is a great prospect for unmethylated CpG DNA as an immunomodulator in the rapy of intestinal diseases．This article illustrated the basic concepts of unmethylated CpG DNA，the characteristics of TLR9．We also reviewed specific applications of unmethylated CpG DNA as adjuvants in modulating intestinal immune responses．At last，we elaborated the research and application prospects of CpG DNA in the future．