人肠道产甲烷菌与肠道健康

Methanogen and human gut health—A review

摘要:

摘要:肠道中甲烷菌可以在严格厌氧的条件下利用H2和碳源生成甲烷，约1/3的正常人体内都可以检测到甲烷。近年来，很多研究发现甲烷菌在维持肠道微生态稳定方面起积极作用，越来越多的研究关注甲烷菌发酵产物(甲烷)在肠道中的代谢，主要集中于甲烷菌与肠道功能失调之间的关系。IBS患者肠道甲烷菌数量常比正常人群少，并且肠道甲烷菌与肥胖症的发生有一定关系。本文对甲烷菌的产甲烷作用在肠道功能稳定方面的作用、甲烷与肠道疾病(肠易激综合症、结肠癌)以及甲烷菌和甲烷与肥胖症的关系进行概述，并从上述几个方面综述肠道产甲烷菌、甲烷与肠道健康的关系。

Abstract:

Abstract:Methane is produced exclusively through anaerobic fermentation of both endogenous and exogenous carbohydrates by methanogens．Methane production is detectable in about one third of healthy adult individuals. In recent years，many studies have found that methanogens played an important role in maintaining stability in the gut microbiota Researches have paid much attention on the metabolism of the methane in the gut． The relationship between methane and intestinal dysfunction has also been investigated. The number of methanogens in irritable bowel syndrome patients is different when compared with the normal individuals. Besides，methanogens are potentially linked with obesity. This article reviewes the role of methanogens in gastrointestinal homeostasis and intestinal diseases (irritable bowel syndrome，colon cancer)，as well as the relation between methanogens and obesity.