结核分枝杆菌信号转导与耐药的研究进展

Signal transduction and drug resistance in Mycobacterium tuberculosis－A review

摘要:

摘要:结核分枝杆菌感染每年导致200万人口死亡，而化疗已经产生了严重的广泛传播的耐药性。信号转导系统是细菌适应周围环境变化的重要分子机制，是否介导细菌耐药性的产生，尚无清楚的认识。本文主要介绍了结核分枝杆菌的12对二元信号转导系统并分析了其与耐药性产生的关系。通过对近期研究的分析，我们发现MprB/A、PhoR/P、DosR/S/T、SenX3/RegX3、MtrB/A五对二元信号转导系统有可能通过不同的机制使结核分枝杆菌对抗结核药物发生耐药性，因此二元信号转导系统是有效的调控靶位点，有可能应用小分子化合物靶向调节二元信号转导途径以逆转耐药。

Abstract:

Abstract: Mycobacterium tuberculosis infection kills two million people every year，and the chemotherapy has led to significant amount of drug resistance． Signal transduction systems are used by bacteria to survive or adapt to their living environment，but the relationship to drug resistance is not well understood． In this article，we introduced the twocomponent signal transduction systems of M． tuberculosis and analyzed their relationship with drug resistance． We identified five two-component system pairs involved in the formation of drug resistance． Therefore，these two-component systems are good targeting sites for small biochemical drugs to target so as to reverse the drug resistance and virulence．