肺炎克雷伯氏菌毒力因子的研究进展

Research advances in the virulence factors of Klebsiella pneumoniae－A review

摘要:

摘要:肺炎克雷伯氏菌(Klebsiella pneumoniae)可天然合成1，3-丙二醇、2，3-丁二醇和3-羟基丙酸等大宗化学品，是近年来的研究热点，但其致病性限制了工业应用。本文综述了该菌的毒力因子，包括菌毛、受体、荚膜多糖、内毒素、铁载体，以及近年报道的其他因子。具体内容涉及毒力因子的编码基因、表达蛋白、参与的代谢活动，以及侵染宿主和抗宿主免疫反应的机制。此外，根据近年来代谢工程和合成生物学领域的新进展，提出了消除或弱化该菌毒性的策略，并对这些策略的可行性进行了讨论。

Abstract:

Abstract:Klebsiella pneumoniae is of great attractiveness because it naturally produces a series of bulk chemicals such as 1，3-propanediol，2，3-butanediol and 3-hydroxypropionic acid．Although this species has been fueled in recent years，its pathogenicity is considered an obstacle hindering industrial applications． Here we portray a picture of the virulence factors，including pili，receptors，capsular polysaccharides，lipopolysaccharides，and newly identified virulence factors．This review covers aspects of virulence genes，proteins，metabolic activities，as well as the mechanisms underlying infection and immune responses． Based on state-of-the-art advances in metabolic engineering and synthetic biology，the strategies for eliminating or attenuating the virulence of K． pneumoniae were proposed，and the feasibilities for these protocols were also briefly discussed.