宿主细胞丝切蛋白(cofilin)与病原微生物感染

The cofilin of host cell and infection-A review

摘要:

摘要:病原微生物侵入宿主细胞是其引发有效感染的必要环节，该过程依赖于宿主细胞内肌动蛋白骨架的重排。丝切蛋白(cofilin)是细胞内一种重要的肌动蛋白解聚因子，参与多种病毒、细菌及真菌的感染过程。病原微生物感染可诱导宿主细胞肌动蛋白发生两相变化，同时伴随cofilin的磷酸化水平改变。通过突变、抑制或过表达改变cofilin 的活性均能有效的抑制病原微生物的感染。本文将对宿主细胞cofilin在病原微生物感染过程中的具体变化及可能的调控机制进行综述。

Abstract:

Abstract:Invasion of pathogens into host cells is the key process to consequently induce the infection，which depends on the actin cytoskeleton rearrangement．Cofilin in the host cell is one of the most important actin depolymerization factor that is essential responsing to the infection of several viruses，bacteria and fungi．Pathogenic microbes can induce biphasic remodeling of the actin cytoskeleton in host cells，accompanied by changes of phosphorylation of cofilin，which results in changes of cofilin activity．The modulation of host cofilin activity by mutation，knockdown，or overexpression can effectively inhibit the infection．Here we review the function and possible regulatory mechanism of host cofilin during the process of infection．