链丝菌素类抗生素的研究进展

Progress in streptothricin antibiotics-A review

摘要:

链丝菌素是人类最早发现的抗生素之一。由于链丝菌素类化合物具有广谱的抗细菌和抗真菌的活性,目前已作为重要的农用抗生素进行应用。本文对链丝菌素的抗性机理、各个组成部分(链里啶内酰胺、氨甲酰化D-古洛糖胺和寡聚β-赖氨酸链)的生物合成机理及链丝菌素类化合物的化学合成等方面的研究进展进行了综述,并对链丝菌素的进一步研究方向进行了展望。

Abstract:

Streptothricins are a group of the earliest discovered antibiotics with broad antimicrobial spectrum, and have been used for crop protection. We reviewed the studies on streptothricin resistance, biosynthesis of the three components (streptolidine, carbamoylated D-glucosamine and poly β-lysine chain) and chemical synthesis of streptothricins. The important aspects for future streptothricin researches were also discussed.