沙门菌致病岛2 Ⅲ型分泌系统研究进展

Advances in Salmonella pathogenicity island 2 type III secretion system-A review

摘要:

沙门菌(Salmonella)是革兰氏阴性的兼性胞内菌,可引起其广泛宿主的一系列疾病,严重时可导致全身性感染,威胁生命安全。沙门菌致病岛2(SPI2)是与沙门菌全身性感染密切相关的重要毒力基因簇,其编码的Ⅲ型分泌系统2(T3SS2)在沙门菌侵入宿主细胞后开始组装合成,经该装置分泌的多种效应蛋白对沙门菌在宿主细胞内的生存和增殖起着重要作用。近些年来,与沙门菌T3SS2相关的研究一直都是病原微生物领域关注的焦点之一。本文简要综述了SPI2的基因特征、SPI2基因表达的调控、T3SS2的结构和组成、T3SS2的效应蛋白及与T3SS2相关的疫苗研究等方面的主要研究进展。

Abstract:

Salmonella is a Gram-negative facultative intracellular pathogen that can infect vast array of hosts and cause a series of diseases, sometimes even life-threatening systemic diseases. As an indispensable virulence determinant associated with the systemic infections, Salmonella pathogenicity island 2 (SPI2) encodes type III secretion system 2 (T3SS2) which is induced after invasion, and the T3SS2 secreted effectors are essential for Salmonella to survive and replicate inside various cell types. In recent years, this issue remains the focus of pathogenic research. This review focuses on the aspects of gene characterization of SPI2, regulation of SPI2 gene expression, the structure and assembly of T3SS2, the T3SS2 effectors and some vaccine candidates associated with T3SS2 to present the current understanding of Salmonella T3SS2.